Results 121 to 130 of about 367,581 (336)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
An Answer Explanation Model for Probabilistic Database Queries [PDF]
, 2007 Following the availability of huge amounts of uncertain data, coming from diverse ranges of applications such as sensors, machine learning or mining approaches, information extraction and integration, etc.
Apers, Peter M.G. +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
BUDDHISM, COMPARATIVE NEUROPHILOSOPHY, AND HUMAN FLOURISHING
Zygon, 2014 Owen Flanagan's The Bodhisattva's Brain represents an ambitious foray into cross‐cultural neurophilosophy, making a compelling, though not entirely unproblematic, case for naturalizing Buddhist philosophy.
doaj +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Wittgenstein and Husserl: Context Meaning Theory [PDF]
, 2016 The present article concentrates on understanding the limits of language from the realm of meaning theory as portrayed by Wittgenstein.
Chakraborty, Dr Sanjit
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Truth, Transcendence, and the Good [PDF]
, 2018 Nietzsche regarded nihilism as an outgrowth of the natural sciences which, he worried, were bringing about “an essentially mechanistic [and hence meaningless] world.” Nihilism in this sense refers to the doctrine that there are no values, or that ...
Bourke, Michael
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Emotions & judgments : a critique of Solomon : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Philosophy at Massey University [PDF]
, 1997 The idea that we are passive victims of our emotions, that they are wild and uncontrollable things which just happen to (or "in") us is very common.
Short, Celia Ruth
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