Results 121 to 130 of about 176,859 (312)

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

He was thinking

open access: yesFilosofický časopis
An obituary for Professor Daniel C. Dennett which offers a comprehensive overview of his entire philosophical project. It is argued that Dennett, drawing on the results and methods of cognitive sciences and evolutionary biology, attempted a unique ...
Hříbek, Tomáš
doaj   +1 more source

Propositional Attitudes, Intentionality and Lawful Behaviors

open access: yesPrincipia: An International Journal of Epistemology, 2003
This paper aims to discuss Quine’s last analysis of propositional attitudes as involving intentionality and as regards human action and the very subject matter of social sciences.
Luiz Henrique de A. Dutra
doaj  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Franz Brentano in Vienna [PDF]

open access: yes, 2020
This paper is the general introduction to a collection of essays entitled Franz Brentano and Austrian Philosophy (forthcoming). In this substantial introduction, I comment several aspects of the recent reception of Brentano’s philosophical programme in ...
Fisette, Denis
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Is Having Contradictory Beliefs Possible? Discussion and Critique of Arguments for the Psychological Principle of Non-Contradiction

open access: yesStudia Semiotyczne, 2020
DOI: http://doi.org/10.26333/stsen.xxxi.04 The aim of this paper is to present and analyze arguments provided for the Psychological Principle of Non-Contradiction which states that one cannot have, or cannot be described as having, contradictory ...
doaj  

Listening as a generous act

open access: yesHandelingen
Listening is a key component of pastoral care, yet practitioners often find it a challenge. In this article, we will examine active listening, which engages not only auditory faculties but also has visual, bodily, and affective dimensions.
Rianne Binnenmars
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

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