Results 101 to 110 of about 178,540 (295)
Report of Cerebellar Hypoplasia in Three Calves
Brazilian Journal of Veterinary Pathology, 2013 Hereditary or acquired cerebellar hypoplasia (CH) is commonly diagnosed in Holstein, Guernsey, Shorthorn and Jersey cattle. Bovine viral diarrhea (BVD) has been associated to acquired CH due to viral infection during the second trimester of pregnancy ...
Daniela Junqueira de Queiroz +6 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Journal of Neurodevelopmental Disorders, 2019 Background Individuals with premutation alleles of the fragile X mental retardation 1 (FMR1) gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS) during aging.
Zheng Wang +4 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Filosofický časopisAn obituary for Professor Daniel C. Dennett which offers a comprehensive overview of his entire philosophical project. It is argued that Dennett, drawing on the results and methods of cognitive sciences and evolutionary biology, attempted a unique ...
Hříbek, Tomáš
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Dignāga and Dharmakīrti on Perception and Self-Awareness [PDF]
, 2016 Like many of their counterparts in the West, Buddhist philosophers realized a long time ago that our linguistic and conceptual practices are rooted in pre-predicative modes of apprehension that provide implicit access to whatever is immediately present ...
Coseru, Christian
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Propositional Attitudes, Intentionality and Lawful Behaviors
Principia: An International Journal of Epistemology, 2003 This paper aims to discuss Quine’s last analysis of propositional attitudes as involving intentionality and as regards human action and the very subject matter of social sciences.
Luiz Henrique de A. Dutra
doaj
The relevance of ontological commitments [PDF]
, 2014 In this introductory note, I describe my particular view of the notion of ontological commitments as honest and pragmatic working hypotheses that assume the existence (out there) of certain entities represented by the symbols in our theory.
Echenique-Robba, Pablo
core