Results 121 to 130 of about 178,540 (295)

Akrasia – status of weak-willed actions in philosophy of law [PDF]

open access: yes, 2012
Akrasia, or weak-will, is a term denoting a phenomenon when one acts freely and intentionally contrary to his or her better judgment. Discussion of akrasia originates in the Plato's Protagoras where he states that “No one who either knows or believes ...
Banaś, Paweł
core  

Franz Brentano in Vienna [PDF]

open access: yes, 2020
This paper is the general introduction to a collection of essays entitled Franz Brentano and Austrian Philosophy (forthcoming). In this substantial introduction, I comment several aspects of the recent reception of Brentano’s philosophical programme in ...
Fisette, Denis
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Only Friends, Despite the Rumors: Philosophy of Mind's Consciousness and Intentionality [PDF]

open access: yes, 2012
Being evasive as it is, philosophers have often tried to do without consciousness. Despite this, it has played a key role in the endeavours of philosophy of mind, as witnessed by its reputation as a "mark of the mental" and works of philosophers like ...
Chartrand, Louis
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

(WP 2011-02) The Change in Sraffa\u27s Philosophical Thinking [PDF]

open access: yes, 2011
The availability of Piero Sraffa’s unpublished manuscripts and correspondence at Trinity College Library, Cambridge, has made it possible to begin to set out a more complete account of Sraffa’s philosophical thinking than previously could be done with ...
Davis, John
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Basic Action and Practical Knowledge [PDF]

open access: yes, 2019
It is a commonplace in philosophy of action that there is and must be teleologically basic action: something done on an occasion without doing it by means of doing anything else. It is widely believed that basic actions are exercises of skill.
Small, Will
core  

Understanding the Unforeseen via the Intentional Stance

open access: yes2024 IEEE International Conference on Advanced Video and Signal Based Surveillance (AVSS)
We present an architecture and system for understanding novel behaviors of an observed agent. The two main features of our approach are the adoption of Dennett's intentional stance and analogical reasoning as one of the main computational mechanisms for understanding unforeseen experiences.
Stacy, Stephanie   +4 more
openaire   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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