Results 121 to 130 of about 6,483 (275)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Słuszność moralna a dzieło sztuki. Przypadek Knuta Hamsuna
Er(r)go, 2005 David Schauffler Moral Correctness and the Artwork. The Case of Knut Hamsun David Schauffler distinguishes five different levels on which one can consider the relation between art and politics: contextual, intentional, temporal, categorical, and finally ...
David Schauffler
doaj
, 2019 It is well known that people tend to anthropomorphize in interpretationsand explanations of the behavior of robots and otherinteractive artifacts. Scientific discussions of this phenomenontend to confuse the overlapping notions of folk psychology,theory ...
Thellman, Sam,, Ziemke, Tom,
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Folk-Psychological Interpretation of Human vs. Humanoid Robot Behavior: Exploring the Intentional Stance toward Robots. [PDF]
Front Psychol, 2017 Thellman S, Silvervarg A, Ziemke T.
europepmc +1 more source
Social Minded Commitment Management
, 2013 The14th Irish Artificial Intelligence and Cognitive Science Conference (AICS 2003), Trinity College Dublin, Ireland, 17-19 September, 2003Over the past 30 years Artificial Intelligence has fragmented from one broad subject into a cluster of narrow but ...
O'Hare, G. M. P. (Greg M. P.) +3 more
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Background of Politeness Universals
Russian journal of linguistics: Vestnik RUDN, 2014 Early accounts of politeness have been widely criticised for adopting a universalist stance while attempting to account for a phenomenon that is clearly culture-dependent.
Stavros Assimakopoulos
doaj