Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Phenomenological Actualism. A Husserlian Metaphysics of Modality? [PDF]
, 2014 Considering the importance of possible-world semantics for modal logic and for current debates in the philosophy of modality, a phenomenologist may want to ask whether it makes sense to speak of “possible worlds” in phenomenology.
Wallner, Michael
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Las aporías del intencionalismo y la superación hermenéutica: Reflexiones filosóficas en torno a un problema jurídico [PDF]
, 2011 El papel que juegan las intenciones de un autor en la interpretación de los textos ha sido profundamente debatido durante el siglo XX. En este trabajo analizaremos algunos argumentos de la postura intencional, en particular en el campo de derecho, para ...
Blanco Ilari, Juan Ignacio
core
The mind minds minds: The effect of intentional stance on the neural encoding of joint attention [PDF]
, 2019 Nathan Caruana, Genevieve McArthur
openalex +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Only Friends, Despite the Rumors: Philosophy of Mind's Consciousness and Intentionality [PDF]
, 2012 Being evasive as it is, philosophers have often tried to do without consciousness. Despite this, it has played a key role in the endeavours of philosophy of mind, as witnessed by its reputation as a "mark of the mental" and works of philosophers like ...
Chartrand, Louis
core
Formalising the intentional stance 2: a coinductive approach [PDF]
Simon McGregor, timorl, Nathaniel Virgo
openalex +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source