Results 41 to 50 of about 176,077,545 (250)

Biowarfare, bioterrorism and biocrime: A historical overview on microbial harmful applications

Forensic Science International, 2020
Highlights • Microorganisms have been use as weapons since pre-historic times.• Biowarfare is the intentional use of biological agents as weapons in war scenarios.• Bioterrorism is the intentional use of biological agents against a civilian population ...
M. Oliveira, G. Mason-Buck, D. Ballard, W. Branicki, A. Amorim   +4 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Burden of chemical poisoning and contributing factors in the case of the Amhara Region, Ethiopia

BMC Public Health
Background This study aimed to evaluate the burden of chemical poisoning and its associated factors at the Chemical, Biological, Radiological, and Nuclear (CBRN) pilot surveillance sites in the Amhara region, Northwest Ethiopia.
Chalachew Yenew, Melaku Shewaye, Almaw Genet Yeshiwas, Asaye Alamneh Gebeyehu   +3 more
doaj   +1 more source

Emerging biotechnologies: Dual-use potential and strategies to prevent misuse

MIT Science Policy Review
Biotechnologies such as gene editing, bioinformatics, and bioprinting are rapidly advancing and finding impact across medicine and agriculture. Biotechnologies are being made readily available to everyone (democratized), accessible and modifiable via an ...
Emma C. Coltoff, Alexandra L. Davis
semanticscholar   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Guidance on the inactivation or removal of select agents and toxins for future use (7 CFR Part 331, 9 CFR Part 121.3, 42 CFR Part 73.3) [PDF]

The United States Department of Health and Human Services (HHS) and the United States Department of Agriculture (USDA) have established regulatory requirements for the possession, use, and transfer of biological select agents and toxins (BSAT) that have ...

core   +3 more sources

Landscape of Dual-Use Research Governance in Malaysia

Applied biosafety : journal of the American Biological Safety Association
Introduction: Biosafety and biosecurity are critical elements of biorisk management, designed to mitigate the risk associated with intentional or unintentional release or exposure to potentially harmful biological agents.
Saarani Vengadesen, L. Chai, De-Ming Chau   +2 more
semanticscholar   +1 more source

Bioterrorism: toxins as potential biological weapons - an emerging global health threat

International Journal of Infectious Diseases, 2019
Purpose: Intentional bioterrorism attacks have has been recorded throughout history, and research in medical defence against intentional biological threats has become a growing priority.
A. Rossodivita, Alessandro Visconti, T. Saporito, G. Rizzardini   +3 more
semanticscholar   +1 more source