Results 61 to 70 of about 85,515 (264)

Interés nacional

open access: yes, 1996
Declarar de interés nacional el Campamento Juvenil Científico Internacional de Verano, 26, organizado por el Instituto Científico Weizmann de Israel que se llevará a cabo del 10 de julio al 9 de agosto de ...
RODRIGUEZ [Ministro]
core  

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

open access: yesAdvanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong   +6 more
wiley   +1 more source

Water‐Mediated Phosphoryl Wires Stabilize Pathological Tau Fibrils

open access: yesAngewandte Chemie, EarlyView.
Extended 1D phosphoryl “wires” stabilize in‐register amyloid tau fibrils, as demonstrated by multiple‐quantum spin‐counting NMR, TEM, and MD simulations, using fibrils of tau peptide jR2R3‐P301L (tau295–313) with phosphorylation at S305 or Y310. ABSTRACT Hyperphosphorylation of tau is a hallmark of tauopathies, with specific phosphorylation sites ...
Lokeswara Rao Potnuru   +8 more
wiley   +2 more sources

Framing the Falklands/Malvinas War: National interest in the coverage of The London Times, La Nación (Argentina) and El Mercurio (Chile)</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Universum</i>, 2004 </span><br><span class="r_content">El objetivo de este trabajo es analizar el enfoque editorial con que los diarios La Nación, Argentina, El Mercurio, Chile, y The London Times, Gran Bretaña, presentaron la cobertura de la guerra de Malvinas (1982), y el rol que jugó en las decisiones ...</span><br><span class="r_sub"><i>Marina Walker</i></span><br><small><a href="https://doaj.org/article/9b55f79d12e44b6b93cbe61f4a2eac9b" target="_blank" rel="nofollow" title="doaj.org/article/9b55f79d12e44b6b93cbe61f4a2eac9b">doaj</a> </small>   <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.22201/iie.18703062e.2006.88.2210" target="_blank" rel="nofollow">La gran edición del Quijote de Ibarra (1780). Las estampas grabadas por Jerónimo Antonio Gil, Joaquín Fabregat, Rafael Ximeno y Fernando Selma</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Anales del Instituto de Investigaciones Estéticas</i>, 2012 </span><br><span class="r_content">La Biblioteca Nacional de México, actualmente en custodia en el Instituto de Investigaciones Bibliográficas de la Universidad Nacional Autónoma de México, conserva en su Fondo reservado una valiosa colección de ejemplares de El ingenioso ...</span><br><span class="r_sub"><i>Eduardo Báez Macías</i></span><br><small><a href="https://doaj.org/article/f207582e348f4858a46e06272ad933ab" target="_blank" rel="nofollow" title="doaj.org/article/f207582e348f4858a46e06272ad933ab">doaj</a> </small>   <div id="more_5" style="display:none"><a href="/sci_redir.php?doi=10.22201%2Fiie.18703062e.2006.88.2210" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.22201/iie.18703062e.2006.88.2210'); alert('Copied the doi');">copy doi</a> <small>(10.22201/iie.18703062e.2006.88.2210)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_5')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="" target="_blank" rel="nofollow">De interés para tu conocimiento: un 85% de adultos portan el virus de herpes.</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16">, 2006 </span><br><span class="r_content">Más del 85% de personas adultas tanto hombres como mujeres sufren herpes labial (HVS-1) e infecciones genitales (HSV-2) . Todas las infecciones del herpes simplex son caracterizadas por una o más grupos de pequeñas vesículas llenas con fluido claro con ...</span><br><span class="r_sub"><i>Consejo Nacional de Ciencia y Tecnología (CONACYT)</i></span><br><small><a href="https://core.ac.uk/works/174095" target="_blank" rel="nofollow" title="core.ac.uk/works/174095">core</a> </small>   <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/advs.75839" target="_blank" rel="nofollow">A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Advanced Science, EarlyView.</i></span><br><span class="r_content">SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.</span><br><span class="r_sub"><i>Qian Tang<span id="ma_7" style="display:none">, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_7')">+33 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/advs.75839?mi=2or9o2m&af=R&AllField=interés nacional&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/advs.75839?mi=2or9o2m&af=R&AllField=interés nacional&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_7" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Fadvs.75839" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/advs.75839'); alert('Copied the doi');">copy doi</a> <small>(10.1002/advs.75839)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_7')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/ange.4046829" target="_blank" rel="nofollow">Catalytic Functionalization of Unactivated π‐Bonds Enabled by Bidentate Directing Auxiliaries</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Angewandte Chemie, EarlyView.</i></span><br><span class="r_content">This review explores how bidentate directing auxiliaries have advanced transition‐metal catalysis for unactivated alkene/alkyne functionalization. By leveraging chelated intermediates, bidentate directing auxiliaries enable precise hydrofunctionalization, difunctionalization, and C─H activation of π‐bonds with unique selectivity and reactivity.</span><br><span class="r_sub"><i>Seunghyeon Cho<span id="ma_8" style="display:none">, Al Vicente Riano D. Lisboa, Juntao Sun, Taeho Kang, Keary M. Engle</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_8')">+4 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/ange.4046829?mi=2or9o2m&af=R&AllField=interés nacional&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/ange.4046829?mi=2or9o2m&af=R&AllField=interés nacional&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Fange.4046829" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="https://onlinelibrary.wiley.com/doi/10.1002/anie.4046829?mi=2or9o2m&af=R&AllField=interés nacional&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/anie.4046829?mi=2or9o2m&af=R&AllField=interés nacional&ConceptID=15941&content=articlesChapters&target=default">wiley.com</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/ange.4046829'); alert('Copied the doi');">copy doi</a> <small>(10.1002/ange.4046829)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+2 more sources</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.15332/s1900-0448.2019.0050.06" target="_blank" rel="nofollow">Obstáculos y fortalezas del régimen legal que protege los bienes de interés cultural del ámbito nacional</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Revista IUSTA</i>, 2019 </span><br><span class="r_content">Por medio de este escrito se pretende dar a conocer el régimen legal que cobija a los bienes de interés cultural del ámbito nacional, partiendo de un análisis minucioso y descriptivo que permita al lector conocer detalladamente sobre el marco legal, su ...</span><br><span class="r_sub"><i>Anny Yahaira Riveros Rojas</i></span><br><small><a href="https://doaj.org/article/2a97fb9c8ba742e3b06cf24962160727" target="_blank" rel="nofollow" title="doaj.org/article/2a97fb9c8ba742e3b06cf24962160727">doaj</a> </small>   <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.15332%2Fs1900-0448.2019.0050.06" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.15332/s1900-0448.2019.0050.06'); alert('Copied the doi');">copy doi</a> <small>(10.15332/s1900-0448.2019.0050.06)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="" target="_blank" rel="nofollow">De interés para tu conocimiento: reconstrucción del virus de 1,918 de la gripe española.</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16">, 2006 </span><br><span class="r_content">La gripe española o pandemia gripal del año de 1,918 fue un hecho histórico de la medicina ya que que mató a más de 50 millones de personas, mediante la denominación deriva de los aliados de la Primera Guerra Mundial, a causa del despliegues noticioso ...</span><br><span class="r_sub"><i>Consejo Nacional de Ciencia y Tecnología (CONACYT)</i></span><br><small><a href="https://core.ac.uk/works/173583" target="_blank" rel="nofollow" title="core.ac.uk/works/173583">core</a> </small>   <br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-pol%C3%ADtica_exterior/" class="suggestion"onclick="show_loader();"><b>política exterior</b></a><br/><a href="/q-malaria/" class="suggestion"onclick="show_loader();"><b>malaria</b></a><br/><a href="/q-la_plata/" class="suggestion"onclick="show_loader();"><b>la plata</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-argentina/" class="suggestion"onclick="show_loader();"><b>argentina</b></a><br/><a href="/q-testosterone/" class="suggestion"onclick="show_loader();"><b>testosterone</b></a><br/></div></div></div><div class="pagenav"><a href="/q-inter%C3%A9s_nacional/p-6/" rel="nofollow"><b>previous</b></a>   <a href="/q-inter%C3%A9s_nacional/p-5/" rel="nofollow">5</a>  <a href="/q-inter%C3%A9s_nacional/p-6/" rel="nofollow">6</a>  <b>7</b>  <a href="/q-inter%C3%A9s_nacional/p-8/" rel="nofollow">8</a>  <a href="/q-inter%C3%A9s_nacional/p-9/" rel="nofollow">9</a>   <a href="/q-inter%C3%A9s_nacional/p-8/" id="next" rel="nofollow"><b>next</b></a> </div><br></div> </div> <script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; 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