Results 121 to 130 of about 2,790,316 (228)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Cortical and white matter myelination proceed in concert during early infancy

Nature Communications
The infant brain undergoes rapid myelination that is critical for healthy brain function. This development has been characterized for gray and white matter independently, but the link between gray and white matter myelination remains unexplored. To close
Stephanie Zika, Kelly Chang, Altan Orhon, John Kruper, Christina Tyagi, Xiaoqian Yan, Sarah Tung, Kalanit Grill-Spector, Ariel Rokem, Mareike Grotheer   +9 more
doaj   +1 more source

Inter-brain desynchronization in social interaction: a consequence of subjective involvement?

Frontiers in Human Neuroscience
Hyperscanning approaches to human neuroscience aim to uncover the neural mechanisms of social interaction. They have been largely guided by the expectation that increased levels of engagement between two persons will be supported by higher levels of ...
Tom Froese, Chen Lam Loh, Finda Putri
doaj   +1 more source

Effects of Hemodynamic Differences on the Assessment of Inter-Brain Synchrony Between Adults and Infants. [PDF]

Front Psychol, 2022
Morimoto S, Minagawa Y.
europepmc   +1 more source

Inter-American Development Bank Sustainability Report 2013 (Report Summary)

, 2014
Long-term economic growth and the reduction of poverty and inequality in Latin America and the Caribbean depend on development that is both socially inclusive and environmentally sustainable.
Inter-American Development Bank
core   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Why behaviour matters: Studying inter-brain coordination during child-caregiver interaction

Developmental Cognitive Neuroscience
Modern technology allows for simultaneous neuroimaging from interacting caregiver-child dyads. Whereas most analyses that examine the coordination between brain regions within an individual brain do so by measuring changes relative to observed events ...
Ira Marriot Haresign, Emily A.M., Phillips, Sam V., Wass   +2 more
doaj   +1 more source

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source