Results 141 to 150 of about 8,082,089 (306)
DESIGNi - a workbench for supporting interaction design
, 2022 S.747-750New devices expand design possibilities, but also lead to more challenges in the creation of interaction forms. This article introduces DESIGNi, a workbench that supports designers in exploring interaction forms and their attributes in a ...
Nass, Claudia +3 more
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Evaluating Peripheral Interaction Design
Many actions in the physical world take place in the background or periphery of peoples attention. However interactions with computing technologies usually require focused attention.
van den Hoven, E, Bakker, S, Eggen, B
core +1 more source
Clinical and Translational ScienceAddressing knowledge gaps at drug approval through drug–drug interaction (DDI)‐related postmarketing requirements (PMRs) and commitments (PMCs) is essential for safe and effective use.
Jingjing Yu +4 more
doaj +1 more source
Toward Competent Robot Apprentices: Enabling Proactive Troubleshooting in Collaborative Robots
MachinesFor robots to become effective apprentices and collaborators, they must exhibit some level of autonomy, for example, recognizing failures and identifying ways to address them with the aid of their human teammates.
Christopher Thierauf +3 more
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
, 1996 34 pages. Appeared in in Proceedings of the 1996 CLiCS Summer School, Isaac Newton Institute, P. Dybjer and A. Pitts, eds.
openaire +3 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Scientific ReportsAs robots are becoming collaborators in various domains, understanding if humans perceive them as moral and intentional agents is pivotal. This study investigated the malleability of human attributions of value alignment and intentionality to a humanoid ...
Serena Marchesi +3 more
doaj +1 more source