Results 31 to 40 of about 330,318 (312)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Interaction Phenomena between Dental Implants and Bone Tissue in Case of Misfit: A Pilot Study
Applied Sciences, 2023 The biomechanical response of cortical and trabecular bone tissues represents a fundamental aspect for the interpretation of the functional response of dental implants.
Chiara Giulia Fontanella +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
WAVE POTENTIAL: A UNIFIED MODEL OF ARTERIAL WAVES, RESERVOIR PHENOMENA AND THEIR INTERACTION
Artery Research, 2016 Models of haemodynamics play a central role in current research directed to understanding and addressing cardiovascular disease. Although conventional windkessel and wave models are very useful, they are incompatible due to conflicting assumptions and ...
Jonathan P. Mynard, Joseph J. Smolich
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Politeness in Ecuadorian Spanish
, 1996 This paper examines politeness phenomena in Ecuadorian Spanish as reflected in the language of telephone conversations, and, as such, attempts to add another cultural perspective to the discussion of politeness issues and of Brown and Levinson's (1978 ...
Placencia, Maria Elena
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Wave potential: A unified model of arterial waves, reservoir phenomena and their interaction☆
Artery Research, 2017 Models of haemodynamics play a central role in current research directed to understanding and addressing cardiovascular disease. Although conventional windkessel and wave models are very useful, they are incompatible due to conflicting assumptions and ...
Jonathan P. Mynard, Joseph J. Smolich
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source