Results 1 to 10 of about 3,269,262 (267)

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

Nature Communications, 2021
Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell ...
Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani   +13 more
doaj   +1 more source

Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome

Nature Communications, 2022
Here, Forster et al. compare 1354 cultured commensal strains (540 species) to 45,403 pathogen strains (12 species), identifying 64,188 MGE-mediated antibiotic resistance gene transfer events between the two groups, and show that 15 broad host range MGEs ...
Samuel C. Forster, Junyan Liu, Nitin Kumar, Emily L. Gulliver, Jodee A. Gould, Alejandra Escobar-Zepeda, Tapoka Mkandawire, Lindsay J. Pike, Yan Shao, Mark D. Stares, Hilary P. Browne, B. Anne Neville, Trevor D. Lawley   +12 more
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ECS1 and ECS2 suppress polyspermy and the formation of haploid plants by promoting double fertilization

eLife, 2023
The current pace of crop plant optimization is insufficient to meet future demands and there is an urgent need for novel breeding strategies. It was previously shown that plants tolerate the generation of triparental polyspermy-derived plants and that ...
Yanbo Mao, Thomas Nakel, Isil Erbasol Serbes, Saurabh Joshi, Dawit G Tekleyohans, Thomas Baum, Rita Groß-Hardt   +6 more
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A symbiotic footprint in the plant root microbiome

Environmental Microbiome, 2023
Background A major aim in plant microbiome research is determining the drivers of plant-associated microbial communities. While soil characteristics and host plant identity present key drivers of root microbiome composition, it is still unresolved ...
Kyle Hartman, Marc W. Schmid, Natacha Bodenhausen, S. Franz Bender, Alain Y. Valzano-Held, Klaus Schlaeppi, Marcel G.A. van der Heijden   +6 more
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Host adaptation in gut Firmicutes is associated with sporulation loss and altered transmission cycle

Genome Biology, 2021
Background Human-to-human transmission of symbiotic, anaerobic bacteria is a fundamental evolutionary adaptation essential for membership of the human gut microbiota.
Hilary P. Browne, Alexandre Almeida, Nitin Kumar, Kevin Vervier, Anne T. Adoum, Elisa Viciani, Nicholas J. R. Dawson, Samuel C. Forster, Claire Cormie, David Goulding, Trevor D. Lawley   +10 more
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Elucidation of Essential Genes and Mutant Fitness during Adaptation toward Nitrogen Fixation Conditions in the Endophyte Azoarcus olearius BH72 Revealed by Tn-Seq

Microbiology Spectrum, 2022
Azoarcus olearius BH72 is a diazotrophic model endophyte that contributes fixed nitrogen to its host plant, Kallar grass, and expresses nitrogenase genes endophytically.
Theresa Harten, Rolf Nimzyk, Vivian E. A. Gawlick, Barbara Reinhold-Hurek   +3 more
doaj   +1 more source

Isopod holobionts as promising models for lignocellulose degradation

Biotechnology for Biofuels, 2020
Background Isopods have colonized all environments, partly thanks to their ability to decompose the organic matter. Their enzymatic repertoire, as well as the one of their associated microbiota, has contributed to their colonization success.
Marius Bredon, Benjamin Herran, Joanne Bertaux, Pierre Grève, Bouziane Moumen, Didier Bouchon   +5 more
doaj   +1 more source

Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis

Scientific Reports, 2022
Lipid transfer proteins (LTPs) were identified as allergens in a large variety of pollens and foods, including cereals. LTPs belong to the prolamin superfamily and display an α-helical fold, with a bundle of four α-helices held together by four disulfide
Hamza Mameri, Jean-Charles Gaudin, Virginie Lollier, Olivier Tranquet, Chantal Brossard, Manon Pietri, Didier Marion, Fanny Codreanu-Morel, Etienne Beaudouin, Frank Wien, Yann Gohon, Pierre Briozzo, Sandra Denery-Papini   +12 more
doaj   +1 more source

Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition – implications for the next generation of DC vaccines

OncoImmunology, 2019
Current treatments for glioblastoma (GBM) have limited efficacy and significant morbidity and therefore new strategies are urgently needed. Dendritic cells have the power to create anti-tumor immune responses. The greater potency of circulating dendritic
Jason Adhikaree, Hester Ann Franks, Constantinos Televantos, Poonam Vaghela, Aanchal Preet Kaur, David Walker, Marc Schmitz, Andrew Mark Jackson, Poulam Manubhai Patel   +8 more
doaj   +1 more source

Parametric mapping of cellular morphology in plant tissue sections by gray level granulometry

Plant Methods, 2020
Background The cellular morphology of plant organs is strongly related to other physical properties such as shape, size, growth, mechanical properties or chemical composition. Cell morphology often vary depending on the type of tissue, or on the distance
David Legland, Fabienne Guillon, Marie-Françoise Devaux   +2 more
doaj   +1 more source