A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Anti-doping literacy scale (ADL-S): development and validation of a French language instrument based on the doping awareness literacy framework. [PDF]
Lanteri T +4 more
europepmc +1 more source
MRI Atlas: Brain (Coronal) - Scan 4 - Labeled
Anatomical structures of the brain are identified in this scan with labeled outline from the UCLA Interactive Neurosciences MRI ...
The Regents of the University of California
core
The ubiquitin system in normal and infected germinal center B cells
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Human Brain Atlas: Brain (Oblique) - Slide 54 - Labeled Outline
Anatomical structures of the brain are identified in this labeled outline from the UCLA Interactive Neurosciences Human Brain ...
The Regents of the University of California
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
From wireframes to immersive reality: a historical perspective on molecular visualization software. [PDF]
Leitão AL, Enguita FJ.
europepmc +1 more source
Human Brain Atlas: Spinal Cord (Sacral) - Slide 101
Anatomical structures of the spinal cord are depicted in this slide from the UCLA Interactive Neurosciences Human Brain ...
The Regents of the University of California
core
Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Service quality and repurchase intention in Chinese live commerce: The mediating role of trust and the moderating effect of generational differences. [PDF]
He C, Bernarte RP.
europepmc +1 more source

