Results 81 to 90 of about 2,553,063 (275)
Scientists in the MIST: Simplifying Interface Design for End Users [PDF]
, 2006 We are building a Malleable Interactive Software Toolkit (MIST), a tool set and infrastructure to simplify the design and construction of dynamically-reconfigurable (malleable) interactive software.
Bhatia, Saurabh +4 more
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Case study in higher school: problems of application and efficiency estimation [PDF]
Современная зарубежная психология, 2015 Case study takes leading positions in training specialists at higher schools in the majority of foreign countries and is regarded as the most efficient way of teaching students how to solve typical professional tasks.
Ekimova V.I.
doaj
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Towards Interactive Logic Programming [PDF]
, 2015 Linear logic programming uses provability as the basis for computation. In the operational semantics based on provability, executing the additive-conjunctive goal $G_1 \& G_2$ from a program $P$ simply terminates with a success if both $G_1$ and $G_2 ...
Kwon, Keehang, Park, Mi-Young
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Virtual Reality Interactive Learning Environment [PDF]
, 2009 Open Building Manufacturing (ManuBuild) aims to promote the European construction industry beyond the state of the art. However, this requires the different stakeholders to be well informed of what ‘Open Building Manufacturing’ actually entails with ...
Alshawi, Mustafa +4 more
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Acquiring Knowledge in Learning Concepts from Electrical Circuits: The Use of Multiple Representations in Technology-Based Learning Environments [PDF]
Journal of Systemics, Cybernetics and Informatics, 2012 The constructivists approach on the conception of relative software of modelling to training and teaching of the concepts of current and voltage requires appraisal of several disciplinary fields in order to provide to the learners a training adapted to ...
Abdeljalil Métioui, Louis Trudel
doaj