Results 321 to 330 of about 63,382 (353)

Rewiring the dynamic interactome

Molecular BioSystems, 2012
Abstract Transcriptomics continues to provide ever-more evidence that in morphologically complex eukaryotes, each protein-coding genetic locus can give rise to multiple transcripts that differ in length, exon content and/or other sequence features. In humans, more than 60% of loci give rise to multiple transcripts in this way.
Davis, Melissa J., Shin, Chang Jin, Jing, Ning, Ragan, Mark A.   +3 more
openaire   +5 more sources

Deciphering the melanoma interactome

Journal of Cutaneous Pathology, 2008
Late‐stage malignant melanoma continues to pose a significant therapeutic challenge, despite numerous recent advances in our understanding of the molecular and genetic pathways leading to tumor development and progression. Dr Scott McNutt was among the first researchers to employ the cutting edge technology, electron microscopy, to the study of ...
openaire   +2 more sources

Defining MAPK Interactomes

ACS Chemical Biology, 2011
The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
openaire   +2 more sources

Analyzing IDPs in Interactomes

2020
Intrinsically disordered proteins (IDPs) and regions (IDRs) are commonly found in all proteomes analyzed so far. These proteins/regions are subject to numerous posttranslational modifications (PTMs) and alternative splicing, are involved in a wide range of cellular functions, and often facilitate protein-protein interactions (PPIs).
openaire   +2 more sources

Interactomics

2004
Proteine liegen in Zellen als Multiproteinkomplexe vor, die entscheidend für die Funktionen von Proteinen und das Verhalten der Zellen sind. Wir haben eine Proteomics-Technologie entwickelt, mit der Proteinkomplexe in nativer Form analysiert werden können: die zweidimensionale Blau-Native-/SDS-Gelelektrophorese von Zelllysaten.
Schamel, W., Camacho-Carvajal, M.
openaire   +1 more source

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome

Cell, 2021
Edward L Huttlin, JOSÉ Navarrete-Perea, Gabriela Zarraga   +2 more
exaly  

The non-coding RNA interactome in joint health and disease

Nature Reviews Rheumatology, 2021
S. Ali, M. Peffers, M. Ormseth, I. Jurisica, M. Kapoor   +4 more
semanticscholar   +1 more source

The Oral Host–Microbial Interactome: An Ecological Chronometer of Health?

Trends in Microbiology, 2021
M Freire, Anna Edlund, Karen E Nelson
exaly  

A host–microbiota interactome reveals extensive transkingdom connectivity

Nature
Nicole D. Sonnert, C. Rosen, Andrew R. Ghazi, E. Franzosa, B. Duncan-Lowey, Jaime A. González-Hernández, John D. Huck, Yi Yang, Yile Dai, Tyler A. Rice, Mytien T. Nguyen, Deguang Song, Yiyun Cao, Anjelica L. Martin, Agata A Bielecka, Suzanne Fischer, Changhui Guan, Julia Oh, C. Huttenhower, A. Ring, Noah W. Palm   +20 more
semanticscholar   +1 more source

A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations

Nature Biotechnology
Dapeng Xiong, Yunguang Qiu, Junfei Zhao, Yadi Zhou, Dongjin Lee, Shobhita Gupta, Mateo Torres, Weiqiang Lu, Siqi Liang, Jin Joo Kang, Charis Eng, Joseph Loscalzo, Feixiong Cheng, Haiyuan Yu   +13 more
semanticscholar   +1 more source