Results 31 to 40 of about 22,703 (264)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Super Spanning Connectivity of the Folded Divide-and-SwapCube
Mathematics, 2023 A k*-container of a graph G is a set of k disjoint paths between any pair of nodes whose union covers all nodes of G. The spanning connectivity of G, κ*(G), is the largest k, such that there exists a j*-container between any pair of nodes of G for all 1 ...
Lantao You, Jianfeng Jiang, Yuejuan Han
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Set-to-Set Disjoint Path Routing in Bijective Connection Graphs
IEEE Access, 2022 The bijective connection graph encompasses a family of cube-based topologies, and $n$ -dimensional bijective connection graphs include the hypercube and almost all of its variants with the order $2^{n}$ and the degree $n$ .
Keiichi Kaneko +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The generalized 3-connectivity of burnt pancake graphs and godan graphs
AKCE International Journal of Graphs and Combinatorics, 2023 The generalized k-connectivity of a graph G, denoted by [Formula: see text] is the minimum number of internally edge disjoint S-trees for any [Formula: see text] and [Formula: see text] The generalized k-connectivity is a natural extension of the ...
Jing Wang, Zuozheng Zhang, Yuanqiu Huang
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Some diameter notions in lexicographic product
Electronic Journal of Graph Theory and Applications, 2018 Many graphs such as hypercubes, star graphs, pancake graphs, grid, torus etc are known to be good interconnection network topologies. In any network topology, the vertices represent the processors and the edges represent links between the processors. Two
Chithra MR +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source