Results 51 to 60 of about 258,364 (276)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Opto-PCB: Three demonstrators for optical interconnections [PDF]

, 2008
We report on a research project targeting optical waveguide integrated PCBs conducted within the European FP6 Network of Excellence on Micro-Optics NEMO.
Alajoki, T., Debaes, C., Destouches, N., Franc, J., Hendrickx, Nina, Karioja, P., Karppinen, M., Parriaux, O., Suyal, H., Taghizadeh, M., Thienpont, H., Van Daele, Peter, Van Erps, J., Van Steenberge, Geert, Vervaeke, M.   +14 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

THE IMPACT OF TRANSMISSIONS 110 kV ON THE LEVEL OF POWER LOSSES IN MOLDAVIAN POWER SYSTEM

Problems of the Regional Energetics, 2012
The paper present the simulation results of system operation in conditions of energy exchange with Ukraine considering the level of power losses in Moldova.
Kalinin L., Zaitsev D., Tirsu M., Golub I.   +3 more
doaj  

World Decarbonization through Global Electricity Interconnections

Energies, 2018
The challenge of worldwide energy decarbonization is crucial to ensure sustainable development. The achievement of decarbonization encompasses not only a considerable exploitation of renewable energy sources, but also a paradigm shift in final energy ...
Ettore Bompard, Daniele Grosso, Tao Huang, Francesco Profumo, Xianzhang Lei, Duo Li   +5 more
doaj   +1 more source

Towards Low Cost Coupling Structures for Short-Distance Optical Interconnections [PDF]

, 2007
The performance of short distance optical interconnections in general relies very strongly on coupling structures, since they will determine the overall efficiency of the system to a large extent.
Alajoki, T., Blanc, D., Destouches, N., Franc, J., Hendrickx, N., Karioja, P., Thienpont, H., Van Daele, P., Van Erps, J.   +8 more
core   +3 more sources

Going for a walk: a verbatim play [PDF]

, 2015
"Going for a Walk" is one outcome of an AHRC-funded research project, "Walking Interconnections: Performing Conversations of Sustainability". Led by an interdisciplinary team of academics from the Universities of Bristol, the West of England and Glasgow,
Heddon, Deirdre
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

On interconnections of infinite-dimensional port-Hamiltonian systems [PDF]

, 2004
Network modeling of complex physical systems leads to a class of nonlinear systems called port-Hamiltonian systems, which are defined with respect to a Dirac structure (a geometric structure which formalizes the power-conserving interconnection structure
Pasumarthy, Ramkrishna, Schaft, Arjan J. van der   +1 more
core   +4 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source