Results 61 to 70 of about 708,016 (372)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Using the Tuning Methodology to design the founding benchmark competences for a new academic professional field: the case of Advanced Rehabilitation Technologies

open access: yesTuning Journal for Higher Education, 2016
Designing innovative high quality educational programmes to meet the workforce needs in emerging interdisciplinary areas of practice can present challenges to academics, students, employers and industrial partners.
Ann-Marie Hughes   +4 more
doaj   +1 more source

Post-COVID-19 global health strategies: the need for an interdisciplinary approach

open access: yesAging Clinical and Experimental Research, 2020
For survivors of severe COVID-19 disease, having defeated the virus is just the beginning of an uncharted recovery path. What follows after the acute phase of SARS-CoV-2 infection depends on the extension and severity of viral attacks in different cell ...
F. E. R. M. A. C. R. F. G. A. F. M. R. A. M. E. C. F. Landi Gremese Bernabei Fantoni Gasbarrini Settanni   +82 more
semanticscholar   +1 more source

Delayed Impact of Interdisciplinary Research [PDF]

open access: yesarXiv, 2022
Interdisciplinary research increasingly fuels innovation, and is considered to be a key to tomorrow breakthrough. Yet little is known about whether interdisciplinary research manifests delayed impact. Here, we use the time to reach the citation peak to quantify the highest impact time and citation dynamics, and examine its relationship with ...
arxiv  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Consumer effects of front-of-package nutrition labeling: an interdisciplinary meta-analysis

open access: yesJournal of the Academy of Marketing Science, 2019
As consumers continue to struggle with issues related to unhealthy consumption, the goal of front-of-package (FOP) nutrition labels is to provide nutrition information in more understandable formats.
Iina Ikonen   +3 more
semanticscholar   +1 more source

Mixing Patterns in Interdisciplinary Collaboration Networks: Assessing Interdisciplinarity Through Multiple Lenses [PDF]

open access: yesarXiv, 2020
There are inherent challenges to interdisciplinary research collaboration, such as bridging cognitive gaps and balancing transaction costs with collaborative benefits. This raises the question: Does interdisciplinary research necessarily result in interdisciplinary collaborations?
arxiv  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Promotion and tenure policies for team science at colleges/schools of medicine

open access: yesJournal of Clinical and Translational Science, 2019
Introduction:Advancing understanding of human health promotion and disease prevention and treatment often requires teamwork. To evaluate academic medical institutions’ support for team science in the context of researchers’ career development, we ...
Susan M. McHale   +5 more
doaj   +1 more source

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