Results 51 to 60 of about 49,257,964 (298)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Structural atlas of the intact jumbo phage phiKZ

Nature Communications
Jumbo phage phiKZ, a key model for studying phage nucleus formation and bacterial defense mechanisms, possesses a highly complex tail machine that is essential for infection.
Hao Xiao, Zeng Peng, Junquan Zhou, Yuan Chen, Yuning Peng, Yixiong Tang, Tao Li, Wenyuan Chen, Sheng-You Huang, Lingpeng Cheng, Hongrong Liu   +10 more
doaj   +1 more source

A Novel Bidirectional Output Oscillating-Amplifying Integrated Fiber Laser With 2 Ports × 2 kW Level Near-Single-Mode Output

IEEE Photonics Journal, 2023
A novel bidirectional output oscillating-amplifying integrated fiber laser which combines the advantages of the bidirectional output fiber laser oscillator and the oscillating-amplifying integrated fiber laser is proposed and demonstrated experimentally.
Jiaqi Liu, Lingfa Zeng, Peng Wang, Baolai Yang, Xiaoming Xi, Chen Shi, Hanwei Zhang, Xiaolin Wang, Fengjie Xi   +8 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

4.8-μm CO-filled hollow-core silica fiber light source

Light: Science & Applications
Mid-infrared (MIR) fiber lasers are important for a wide range of applications in sensing, spectroscopy, imaging, defense, and security. Some progress has been made in the research of MIR fiber lasers based on soft glass fibers, however, the emission ...
Xuanxi Li, Linyong Yang, Zhiyue Zhou, Zhixian Li, Hao Li, Wenxi Pei, Wei Huang, Jing Shi, Luohao Lei, Meng Wang, Zefeng Wang   +10 more
doaj   +1 more source

Interventions at the end of life – a taxonomy for ‘overlapping consensus’ [version 1; referees: 2 approved]

Wellcome Open Research, 2017
Context: Around the world there is increasing interest in end of life issues. An unprecedented number of people dying in future decades will put new strains on families, communities, services and governments.
David Clark, Hamilton Inbadas, Ben Colburn, Catriona Forrest, Naomi Richards, Sandy Whitelaw, Shahaduz Zaman   +6 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effects of automatic and explicit parenting on adolescents’ alcohol use

Cogent Psychology, 2022
Commonly, parenting behaviors are assessed in an explicit way, usually by means of self-reports. Yet under suboptimal conditions, it is expected that parents act more automatically.
I.M. Koning, S.M. Doornwaard, V.G. Van der Rijst, J. De Houwer, W. Vollebergh   +4 more
doaj   +1 more source

Interdisciplinary Studies and Comparative Literature in China and the West

, 2013
In his article "Interdisciplinary Studies and Comparative Literature in China and the West" Aaron Lee Moore addresses the arguments on the part of Chinese and Western scholars against and for the full inclusion of interdisciplinary studies within the ...
A. L. Moore
semanticscholar   +1 more source

Social media for intelligent public information and warning in disasters: An interdisciplinary review

International Journal of Information Management, 2019
Social media offers participatory and collaborative structure and collective knowledge building capacity to the public information and warning approaches. Therefore, the author envisions the intelligent public information and warning in disaster based on
Cheng Zhang, Chao Fan, Wenlin Yao, Xia Hu, A. Mostafavi   +4 more
semanticscholar   +1 more source