Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Delta and Gamma hedging of mortality and interest rate risk [PDF]
This paper studies the hedging problem of life insurance policies, when the mortality and interest rates are stochastic. We focus primar- ily on stochastic mortality. We represent death arrival as the rst jump time of a doubly stochastic process, i.e.
Elisa Luciano, Luca Regis, Elena Vigna
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Interest rates in open economies : real interest rate parity, exchange rates, and country risk in industrial and developing countries [PDF]
The paper tests for the relative importance of international capital market integration in determining interest rates in a broad sample of both industrial and developing countries.
DEC, Das Gupta, Bejoy, Das Gupta, Dipak
core
Pricing Convertible Bonds with Interest Rate, Equity, Credit and FX Risk [PDF]
Convertible bonds are hybrid securities whose pricing relies on a set of complex inter-dependencies due to the sensitivity to interest rate risk, underlying (equity) risk, FX risk, and credit risk, and due to the convertible bond’s early exercise ...
Ali Bora Yigitbasioglu
core +2 more sources
Interest Rate Risk and Financial Performance of Commercial Banks in Kenya
The purpose of the study was to determine the effect of interest rate risk on the financial performance of commercial banks in Kenya. The study adopted a positivist research philosophy. An explanatory research design was applied.
Lynette Chelangat Musani +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Risk premia in Australian interest rates [PDF]
The level of and movements in interest rates and the exchange rate can have a substantial impact on the economic performance of Australia's primary industries.
Douglas, Justin J., Bartley, Scott W.
core
Liquidity Risk, Credit Risk and the Overnight Interest Rate Spread: A Stochastic Volatility Modelling Approach [PDF]
In this paper we model the volatility of the spread between the overnight interest rate and the central bank policy rate (the policy spread) for the euro area and the UK during the two main phases of the financial crisis that began in late 2007.
John Beirne +2 more
core +2 more sources

