Results 111 to 120 of about 15,272,143 (302)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Scenario Based Principal Component Value-at-Risk: an Application to Italian Banks' Interest Rate Risk Exposure [PDF]
The paper develops a Value-at-Risk methodology to assess Italian banksÂ’ interest rate risk exposure. By using 5 years of daily data, the exposure is evaluated through a Principal Component VaR based on Monte Carlo simulation according to two different ...
Simonetta Iannotti, Roberta Fiori
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Financial liberalisation and interest rate risk management in sub-Saharan Africa [PDF]
The appropriateness of financial liberalisation in Africa - at least over the short-term - is in doubt. It has been suggested that the credit risks faced by financial institutions will be detrimental to the supply of credit.
Willem Naudé
core
Impact of Financial Risk on Profitability: Evidence from Nigerian Deposit Money Banks
FUDMA Journal of Accounting and Finance Research (FUJAFR)The paper assesses the influence of financial risk on profitability of listed Nigerian Deposit money banks (DMBs). Profitability was proxied with return on assets (ROA), whereas financial risk as a predictor is measured with Liquidity Risk (LQR ...
Musa Muhammad Bello +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Exchange Rate Dynamics under Alternative Optimal Interest Rate Rules [PDF]
We explore the role of interest rate policy in the exchange rate determination process. Specifically, we derive exchange rate equations from interest rate rules that are theoretically optimal under a few alternative settings.
Yin-Wong Cheung, Mahir Binici
core
Taxation, risk and real interest rates [PDF]
, 1993 It is an established orthodoxy that negative real interest rates constrain development, by causing financial repression.' The World Bank and the International Monetary Fund (IMF) frequently make the raising of nominal interest rates above the rate of inflation a condition of their lending; and some countries without IMF or World Bank programmes have ...
Carolyn Jenkins, Charles Harvey
openaire +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
An economic capital model integrating credit and interest rate risk in the banking book [PDF]
Banks typically determine their capital levels by separately analysing credit and interest rate risk, but the interaction between the two is significant and potentially complex. We develop an integrated economic capital model for a banking book where all
Alessandri, Piergiorgio +1 more
core