Results 111 to 120 of about 3,854,105 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Influence of the Russian-American Relations on Kazakhstan at the Present Stage
Управленческое консультирование, 2018 In the article various aspects of influence of the Russian-American relations on Kazakhstan at the present stage are considered. Special attention is paid to the Kazakh vector of the American policy and the relation of Russia.
R. Yu. Rybkin
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2009 This study examines the impact of political interests of the Blair Government on the development of the NHS star rating system. It argues that the use of performance measurements (PMs) is not detached from its political context but influenced by ...
Chang, Li-cheng, Chang, L.C.
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 1945 A letter from the Legation of Switzerland, Department of Japanese Interests, Special Division to Kikoshi [Kiyoshi] Uyekawa, stating that Mitsuye Uyekawa's application for repatriation to Japan has been canceled.
Legation of Switzerland. Department of Japanese Interests
core
Shrouded histories: Outlaw and Lawmaker, Republican politics and Women's Interests
, 2003 This essay reads the novel of expatriate colonial writer Rosa Praed, Outlaw and Lawmaker (1893), as an intervention in the public debate about the Irish question and the marriage question which were vigorously discussed in the late 1880s in Britain, the ...
Ferres, Kay
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Trade-union movement in kazakhstan: problems and prospects
Хабаршы. Психология және социология сериясы, 2016 The main function of the trade-union organizations is consolidation of interests of workers and protection of their interests before the employer. The history of development of trade unions shows how difficult it is to satisfy needs of workers in the ...
Zh. Nurbekova +2 more
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