Results 91 to 100 of about 1,902,719 (318)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Technologies, 2018 New technology always needs validation in terms of stakeholder acceptance and usability. This challenge also applies in the case of technology for reminiscence therapy for people with dementia.
Peter Klein, Martina Uhlig, Hannes Will
doaj +1 more source
, 2015 Contém os nomes do Comitê Científico e Conselho Editorial da Revista ...
Editorial, Conselho Editorial
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Product-process interface for effective product design and manufacturing in a DFM approach [PDF]
, 2009 This research work is partly supported by SNECMA enterprise. It makes part of the MAIA 8 projectIn order to tackle a continuous improvement of virtual engineering, product modelling has to integrate always more knowledge that refer to every decision ...
El Gueder, Jawhar +4 more
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Phosphorylation at the Interface [PDF]
Structure, 2011 Proteomic studies have identified thousands of eukaryotic phosphorylation sites (phosphosites), but few are functionally characterized. Nishi et al., in this issue of Structure, characterize phosphosites at protein-protein interfaces and estimate the effect of their phosphorylation on interaction affinity, by combining proteomics data with protein ...
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
FreeForm: An informal environment for interface prototyping
, 2002 Best practice in interface design suggests that hand-drawn sketches are preferable at the early stages of the design process. This paper describes the FreeForm software which supports informal sketched interface design by acting as a Visual Basic Add-In.
Beryl Plimmer +5 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
AVALIADORES AD HOC - REVISTA INTERFACE 2016
, 2016 A Direção da INTERFACE agradece a contribuição de professores e pesquisadores na avaliação dos ...
Editorial, Conselho Editorial
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