Results 81 to 90 of about 1,902,719 (318)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Nature Chemistry, 2015 Porphyrins and other tetrapyrrole macrocycles possess an impressive variety of functional properties that have been exploited in natural and artificial systems. Different metal centres incorporated within the tetradentate ligand are key for achieving and regulating vital processes, including reversible axial ligation of adducts, electron transfer ...
Willi Auwärter +3 more
openaire +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Journal of NeuroEngineering and RehabilitationBackground Brain-Machine Interfaces (BMI) based on motor imagery (MI) are promising assistive neurotechnology tools for gait rehabilitation that allow users to control exoskeletons by imagining motor actions.
Paula Soriano-Segura +4 more
doaj +1 more source
Barrier dysfunction or drainage reduction: differentiating causes of CSF protein increase
Fluids and Barriers of the CNS, 2017 Background Cerebrospinal fluid (CSF) protein analysis is an important element in the diagnostic chain for various central nervous system (CNS) pathologies.
Mahdi Asgari +2 more
doaj +1 more source
Transforming graphical interfaces into auditory interfaces
Conference companion on Human factors in computing systems - CHI '95, 1995 This work explores transforming graphical interfaces into auditory interfaces. By transparently transforming graphical application written with a commercial toolkit, I have been able to investigate strategies for generically modeling graphical interfaces.
openaire +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Scientific ReportsThe capacitive measurement of the head’s dielectric properties has been recently proposed as a noninvasive method for deriving surrogates of craniospinal compliance (CC), a parameter used in the evaluation of space-occupying neurological disorders.
Andrea Boraschi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Mobile Brain-Body Imaging and Visual Data of Theatrical Actors During Rehearsal and Performance
Scientific DataThis longitudinal Mobile Brain-Body Imaging dataset was acquired during six rehearsal sessions and three public performances of a scene from a play with highly emotional components.
Manuel Flurin Hendry +14 more
doaj +1 more source