Results 61 to 70 of about 2,592,637 (335)

Numerical buckling analysis of cracked Bi-material thin plates

Advances in Mechanical Engineering, 2020
The aim of this present study is to analyze numerically the buckling behavior of cracked thin bi-material structures subjected to compression and tensile stresses and this, by considering the evolution of crack lengths and its orientations at the ...
Sara Ould Hamouda, Nabil Kazi Tani, Tawfik Tamine   +2 more
doaj   +1 more source

Fracture analysis-based mode-I stress intensity factors of crack under fracture grouting in elastic–plastic soils

Scientific Reports, 2023
For the interaction of crack on the soil–grout interface under fracture grouting, an approximate method to determine the stress intensity factor (SIF) of crack on the soil–grout interface was proposed based on the conservation J 2-integral.
Long Li, Yousheng Deng
doaj   +1 more source

Single and double edge interface crack solutions under arbitrary material combinations [PDF]

, 2012
In this paper interfacial edge crack problems are considered by the application of the finite element method. The stress intensity factors are accurately determined from the ratio of crack-tip-stress value between the target given unknown and reference ...
Lan Xin, Muchinaka Kengo, Noda Nao-Aki, Zhang Yu   +3 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Performance and mechanism of crack prevention measures at interface between rammed earth supplement and original body in the erosion area of rammed earth sites

Yantu gongcheng xuebao
The interface cracking between the rammed earth supplement and the original site body, after construction, is a common issue for the reinforcement of the erosion area at the base of rammed earth sites.
CUI Kai 1, 2 , XU Pengfei 1, 2, YU Xiangpeng 1, 2, SHAO Hui'an 1, 2, WEI Xin 1, 2
doaj   +1 more source

Investigation of compact tensile and fracture mechanical properties of a duplex stainless steel bimetal composite with the interfacial zone

Journal of Materials Research and Technology, 2022
The interfacial zone formed in the manufacturing process of bimetal or laminated metal composites owes complicated microstructures and properties. This special feature greatly affects the fracture toughness and fatigue strength of metal composites.
Zhou Li, Y.C. Lin, Lu Zhang, Fanghui Jia, Zhengyi Jiang, Sihai Jiao   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Crack propagation in non-homogenous materials: Evaluation of mixed-mode SIFs, T-stress and kinking angle using a variant EFG method [PDF]

, 2016
A new variant of the Element-Free Galerkin (EFG) method, that combines the diffraction method, to characterize the crack tip solution, and the Heaviside enrichment function for representing discontinuity due to a crack, has been used to model crack ...
Falzon, B. G., Maiti, S. K., Muthu, N., Yan, Wenyi   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multiscale modeling of interfacial mechanical behaviours of SiC/Mg nanocomposites

Materials & Design, 2019
The aim of this investigation is to predict the interface separation behavior of silicon carbide (SiC) reinforced magnesium (Mg) matrix composites via multiscale simulations.
Xia Zhou, Wenming Bu, Shangyu Song, Frederic Sansoz, Xiaorun Huang   +4 more
doaj   +1 more source