Results 81 to 90 of about 2,592,637 (335)

A phase-field method for modeling cracks with frictional contact

, 2019
We introduce a phase-field method for continuous modeling of cracks with frictional contacts. Compared with standard discrete methods for frictional contacts, the phase-field method has two attractive features: (1) it can represent arbitrary crack ...
Choo, Jinhyun, Fei, Fan
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Optical investigation of crack initiation and propagation during the single fibre pull-out test

Results in Materials
The single fibre pull-out test is an important micromechanical test used to evaluate the fibre-matrix interface of polymer matrix composites primarily under shear stress.
Carol Winnifred Rodricks, Gerhard Kalinka   +1 more
doaj   +1 more source

Frictional interface crack-tip singular stress field in anisotropic [PDF]

, 2013
This study presents the asymptotic displacement and stress fields at the crack tip of frictional interface where slip can occur along the interface between two anisotropic composite laminates.
Chen, Hua-Peng
core  

The scattering of general SH plane wave by interface crack between two dissimilar viscoelastic bodies [PDF]

, 1999
The scattering of general SH plane wave by an interface crack between two dissimilar viscoelastic bodies is studied and the dynamic stress,intensity factor at the crack-tip is computed.
Li RKY, Wei, PJ (reprint author), Chinese Acad Sci, Inst Mech, Lab Nonlinear Mech Continous Media, Beijing 100080, Peoples R China., 吴永礼, 张双寅, 魏培君   +4 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

A new data reduction scheme to obtain the mode II fracture properties of Pinus Pinaster wood [PDF]

, 2006
In this work a numerical study of the End Notched Flexure (ENF) specimen was performed in order to obtain the mode II critical strain energy released rate (GIIc) of a Pinus pinaster wood in the RL crack propagation system.
Morais, A. B. de, Morais, J. J. L., Moura, M. F. S. F. de, Silva, M. A. L.   +3 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Crack-Like Processes Governing the Onset of Frictional Slip

, 2006
We perform real-time measurements of the net contact area between two blocks of like material at the onset of frictional slip. We show that the process of interface detachment, which immediately precedes the inception of frictional sliding, is governed ...
A Cochard, A Needleman, AE Filippov, AJ Rosakis, AJ Rosakis, AT Linde, BJ Briscoe, CH Scholz, CJ Ammon, D Coker, D Coker, DJ Andrews, DJ Andrews, FF Abraham, G Rogers, Gil Cohen, HJ Gao, JA Greenwood, Jay Fineberg, JF Archard, JH Dieterich, JR Rice, K Ravi-Chandar, KW Xia, L Crescentini, L Kogut, L Kogut, LB Freund, M Bouchon, M Ohnaka, M Urbakh, Meni Shay, MH Muser, N Lapusta, R Bilham, R Buczkowski, S Bouissou, S Ciliberto, Shmuel M. Rubinstein, SM Rubinstein, T Baumberger, T Lay, TH Heaton, Y Ben-Zion, Y Ben-Zion   +44 more
core   +1 more source