Results 61 to 70 of about 178,578 (290)

Study on crack propagation law of hydraulic fracturing of coal rock complex based on cohesive element

Meikuang Anquan
In order to further analyze the propagation path and evolution law of hydraulic fractures in coal rock complex, from the perspective of stress field, coal rock interface strength and coal seam bedding dip angle, a hydraulic fracture model of coal rock ...
Zhaowei ZHANG
doaj   +1 more source

Modelling of impact damage and permanent indentation on laminate composite plate [PDF]

, 2010
This paper deals with impact damage and permanent indentation modelling. A model enabling the formation of damages developing during a low velocity / low energy impact test on laminate composite panels has been elaborated.
Barrau, Jean-Jacques, Bouvet, Christophe, Rivallant, Samuel   +2 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Experimental and Numerical Study on Fracture Characteristics of Interface between In Situ Engineered Cementitious Composites and Steel Deck

Advances in Materials Science and Engineering, 2021
In this study, engineered cementitious composite (ECC) is used as the pavement of orthotropic steel deck bridge and an epoxy adhesive is used to achieve wet-bonding between the steel deck and cast-in-place ECC.
Weiwei Han, Shuyin Wu, Xue Gao, Xinyao Zong, Jingsong Shan   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Department of Civil Engineering, Faculty of Civil Engineering and Architecture, Lublin University of Technology

Budownictwo i Architektura, 2014
In this paper the results of the research of T-shape cross-section beams with differently located interface are presented. The cracks pattern and the value of the force causing the interface cracking are analysed. Moreover, the influence of the interface
Łukasz Jabłoński
doaj   +1 more source

Effect of Inhomogeneous Mechanical Properties on the Stress-Strain Field at the Crack Tip and Crack Growth Direction in Dissimilar Metal Welded Joints

Science and Technology of Nuclear Installations, 2023
In the failure analysis and safety assessment of dissimilar metal welded joints, the mechanical heterogeneity of local regions is usually ignored and limited sampling locations are selected.
Shuang Wang, Hongkui Zhang, Zhe Ju, Bing Li, Fandong Chen, Fei Han   +5 more
doaj   +1 more source

The investigation of fibre reinforcement effects in thermoplastic materials: interfacial bond strength and fibre end parameter [PDF]

, 2008
Glass fibres used in the manufacture of fibre reinforced thermoplastic composites (FRTP) are normally sized with a film former which includes a silane coupling agent to improve the interfacial bond strength between glass fibre and matrix .
Jones, F.R., Thomason, James, Wang, C.C.
core  

A phase-field method for modeling cracks with frictional contact

, 2019
We introduce a phase-field method for continuous modeling of cracks with frictional contacts. Compared with standard discrete methods for frictional contacts, the phase-field method has two attractive features: (1) it can represent arbitrary crack ...
Choo, Jinhyun, Fei, Fan
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source