Results 51 to 60 of about 68,739 (249)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Numerical study on effects of interfacial roughness and microcracks on stress distribution in thermal barrier coatings with temperature drop

Heliyon
This paper establishes a finite element model that includes the interface roughness characteristics to evaluate the stress concentration in the atmospheric plasma sprayed (APS) thermal barrier coatings (TBCs) with an uneven temperature field.
Mengqi Yu, Ningning Liu, Ruifeng Dou, Linjing Huang, Jian Sun, Zhi Wen, Xunliang Liu   +6 more
doaj   +1 more source

Modeling of turbulent transport term of interfacial area concentration in gas–liquid two-phase flow [PDF]

Nuclear Engineering and Design, 2012
Abstract A modeling of basic transport equation and constitutive equations of turbulent transport terms of interfacial area concentration was carried out. Based on the local instant formulation, interfacial area concentration was formulated in term of spatial correlation functions of characteristic function (local instant volume fraction) and its ...
Isao Kataoka, Kenji Yoshida, Masanori Naitoh, Hidetoshi Okada, Tadashi Morii   +4 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enhanced interfacial strength of carbon fiber/PEEK composites using a facile approach via PEI&ZIF-67 synergistic modification

Journal of Materials Research and Technology, 2019
As a kind of metal-organic frameworks (MOFs) which possess large specific surface area and excellent thermal stability, zeolitic imidazolate framework-67 (ZIF-67) shows great application potentials because it can be synthesized in aqueous solutions at ...
Hansong Liu, Yan Zhao, Na Li, Xiaoran Zhao, Xiao Han, Shuang Li, Wenkuo Lu, Kai Wang, Shanyi Du   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effect of Solid Loading on Carbon Dioxide Absorption in Bubble Column

Al-Khawarizmi Engineering Journal, 2011
In the present work experiments were conducted to study  the effect of solid loading (1,5 and 9 vol.%) on the enhancement of carbon dioxide absorption in bubble column at various volumetric gas flow rate (0.75, 1 and 1.5 m3/h) and absorbent concentration
Alyaa Khadhier Mageed
doaj   +2 more sources

Enhancement of the in-plane and pin-load bearing behavior of a quasi-isotropic carbon fiber/epoxy matrix multi-scale laminate by modifying the fiber-matrix interphase using graphene nanoplatelets

Journal of Materials Research and Technology, 2020
The present work examines the effect of incorporating two different concentrations, 0.1% and 0.25%, of silane-functionalized graphene nanoplatelets GnP-GPTMS onto the carbon fiber surface of a quasi-isotropic laminate with the aim to enhance both, the ...
Abad Arcos-Alomía, Pascual Bartolo-Pérez, Alex Valadez-González, Pedro Jesus Herrera-Franco   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source