Results 51 to 60 of about 70,713 (291)

Modeling of turbulent transport term of interfacial area concentration in gas–liquid two-phase flow [PDF]

Nuclear Engineering and Design, 2012
Abstract A modeling of basic transport equation and constitutive equations of turbulent transport terms of interfacial area concentration was carried out. Based on the local instant formulation, interfacial area concentration was formulated in term of spatial correlation functions of characteristic function (local instant volume fraction) and its ...
Isao Kataoka, Kenji Yoshida, Masanori Naitoh, Hidetoshi Okada, Tadashi Morii   +4 more
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Mechanistic Modeling of Interfacial Area Transport in Large Diameter Pipes

, 2012
Flow in large pipes is important in a wide variety of applications. In the nuclear industry in particular, understanding of flow in large diameter pipes is essential in predicting the behavior of reactor systems.
Ishii, M., Hibiki, T., Schlegel, Joshua P., Smith, T. R.   +3 more
core   +1 more source

Quantitative Analysis of Interfacial Area on Liquid-liquid Multiphase Flow of Transesterification Process in Cross-junction Microchannel Reactor [PDF]

, 2019
Key advantage of microfluidic technology in chemical processing is the high interfacial area which is especially important factors in multiphase reaction. The multiphase reaction like transesterification of vegetable oil and methanol to produce biodiesel
Kushaari, Kuzilati, Hamid, Nor Hisham, Laziz, Afiq Mohd   +2 more
core   +1 more source

Enhanced interfacial strength of carbon fiber/PEEK composites using a facile approach via PEI&ZIF-67 synergistic modification

Journal of Materials Research and Technology, 2019
As a kind of metal-organic frameworks (MOFs) which possess large specific surface area and excellent thermal stability, zeolitic imidazolate framework-67 (ZIF-67) shows great application potentials because it can be synthesized in aqueous solutions at ...
Hansong Liu, Yan Zhao, Na Li, Xiaoran Zhao, Xiao Han, Shuang Li, Wenkuo Lu, Kai Wang, Shanyi Du   +8 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Effect of Solid Loading on Carbon Dioxide Absorption in Bubble Column

Al-Khawarizmi Engineering Journal, 2011
In the present work experiments were conducted to study  the effect of solid loading (1,5 and 9 vol.%) on the enhancement of carbon dioxide absorption in bubble column at various volumetric gas flow rate (0.75, 1 and 1.5 m3/h) and absorbent concentration
Alyaa Khadhier Mageed
doaj   +2 more sources

Enhancement of the in-plane and pin-load bearing behavior of a quasi-isotropic carbon fiber/epoxy matrix multi-scale laminate by modifying the fiber-matrix interphase using graphene nanoplatelets

Journal of Materials Research and Technology, 2020
The present work examines the effect of incorporating two different concentrations, 0.1% and 0.25%, of silane-functionalized graphene nanoplatelets GnP-GPTMS onto the carbon fiber surface of a quasi-isotropic laminate with the aim to enhance both, the ...
Abad Arcos-Alomía, Pascual Bartolo-Pérez, Alex Valadez-González, Pedro Jesus Herrera-Franco   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source