Results 11 to 20 of about 744,029 (294)

Effect of red maca (Lepidium meyenii) on INF-γ levels in ovariectomized rats

Revista Peruana de Medicina Experimental y Salud Pública, 2014
Objectives. Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Materials and methods. Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized ...
Johanna Leiva-Revilla, Félix Guerra-Castañon, Paola Olcese-Mori, Iván Lozada, Julio Rubio, Carla Gonzales, Gustavo F Gonzales   +6 more
doaj   +1 more source

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Cell Reports, 2017
SUMMARY PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade.
A. García-Díaz, D. Shin, B. H. Moreno, Justin D. Saco, Helena Escuin-Ordinas, G. A. Rodriguez, J. Zaretsky, Lu Sun, Willy Hugo, Xiaoyan Wang, Giulia Parisi, Cristina Puig Saus, D. Torrejon, T. Graeber, Begonya Comin-Anduix, S. Hu-Lieskovan, R. Damoiseaux, R. Lo, A. Ribas   +18 more
semanticscholar   +1 more source

Interferon add-on therapy increased clinical cure significantly for interferon-experienced chronic hepatitis B patients with low HBsAg

Frontiers in Immunology, 2022
Currently, interferon add-on therapy brings hope for clinical cure of chronic hepatitis B patients with low HBsAg. However, in clinical practice patients with poor responses to their first interferon therapy were often switched to nucleos(t)ide analog ...
Xiaoan Yang, Xiaoan Yang, Ka Zhang, Ka Zhang, Qihuan Xu, Qihuan Xu, Xin Shu, Xin Shu, Zhishuo Mo, Zhishuo Mo, Dongying Xie, Dongying Xie, Zhiliang Gao, Zhiliang Gao, Hong Deng, Hong Deng   +15 more
doaj   +1 more source

Interferon-Stimulated Genes: What Do They All Do?

Annual Review of Virology, 2019
In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal viral infection. IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs)
J. Schoggins
semanticscholar   +1 more source

The type I interferon response in COVID-19: implications for treatment

Nature reviews. Immunology, 2020
Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection.
Jeong Seok Lee, E. Shin
semanticscholar   +1 more source

Association of autoimmune hepatitis and multiple sclerosis: a coincidence?

Galicia Clínica, 2015
Autoimmune hepatitis is a chronic liver inflammation resulting from deregulation of immune tolerance mechanisms. Multiple sclerosis is also an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged ...
Marta Sofia Mendes Oliveira, Rosa Jorge Saudade, Joana Ricardo Pires   +2 more
doaj   +1 more source

Cloning of human Type I interferon cDNAs

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 2023
In the late 1970s, crude interferon samples were found to exhibit anti-tumour activity. This discovery led to the interferon as a “magic drug” for cancer patients.
Shigekazu NAGATA
doaj   +1 more source

Interferon-α2b Treatment for COVID-19

Frontiers in Immunology, 2020
The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. We describe here the effects of treatment with interferon (IFN)-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China. In
Qiong Zhou, V. Chen, C. Shannon, Xiao-Shan Wei, Xuan Xiang, Xu Wang, Zi-Hao Wang, S. Tebbutt, T. Kollmann, E. Fish   +9 more
semanticscholar   +1 more source

Estudio de la coinfección por el virus de la hepatitis C (VHC) en la cohorte de pacientes infectados por VIH del Hospital Universitario de Basurto: Prevalencia de la coinfección, genotipado, grado de fibrosis y respuesta a los diferentes tratamientos. [PDF]

, 2017
[ES] Este trabajo compara la eficacia de los tratamientos iniciales frente al VHC (interferón-pegilado y ribavirina) respecto a los más nuevos (AADs) en los pacientes coinfectados por VIH/VHC atendidos en nuestro Hospital desde inicios de los 90 hasta la
Gómez Garijo, Marta
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source