Results 1 to 10 of about 492,253 (263)

Expression, purification, and bioactivity of a soluble recombinant ovine interferon-tau in Escherichia coli

Journal of Veterinary Research, 2021
Ovine interferon-tau (oIFN-τ) is a newly discovered type I interferon. This study used biochemical techniques to transform the oIFN-τ gene into Escherichia coli to obtain the mass and soluble expression of the recombinant protein.
Yu Hai-Yang, Gao Dong-Mei, Zhou Wei, Xia Bing-Bing, He Zhi-Yuan, Wu Bo, Jiang Min-Zhi, Wang Ming-Li, Zhao Jun   +8 more
doaj   +1 more source

DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis

Frontiers in Immunology, 2023
BackgroundPsoriasis is an autoimmune/inflammatory disorder primarily affecting the skin. Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately one-third of psoriasis patients.
Valentina Natoli, Valentina Natoli, Amandine Charras, Sigrun R. Hofmann, Sarah Northey, Susanne Russ, Felix Schulze, Liza McCann, Susanne Abraham, Christian M. Hedrich, Christian M. Hedrich   +10 more
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Acute and sub-chronic toxicity study of recombinant bovine interferon alpha in rodents

Journal of Veterinary Research, 2021
Recombinant bovine interferon alpha (rBoIFN-α) has been demonstrated to have antiviral activity. However, no conduct of acute or chronic toxicity tests has been reported.
Yu Hai-Yang, Gao Dong-Mei, Zhou Wei, Xia Bing-Bing, He Zhi-Yuan, Wu Bo, Jiang Min-Zhi, Wang Ming-Li, Zhao Jun   +8 more
doaj   +1 more source

Sirolimus combined with interferon-alpha 2b therapy for giant hepatic epithelioid hemangioendothelioma: a case report

Frontiers in Oncology, 2022
Hepatic epithelioid hemangioendothelioma (HEH) is a very rare tumor originated from vascular endothelial cells, with unpredictable malignancy. No standard treatment has been established yet. Although surgical resection and liver transplantation have been
Xiaolei Liu, Ruiquan Zhou, Shuang Si, Liguo Liu, Shiwei Yang, Dongdong Han, Haidong Tan   +6 more
doaj   +1 more source

Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients

Frontiers in Immunology, 2023
BackgroundDexamethasone improves the survival of COVID-19 patients in need of supplemental oxygen therapy. Although its broad immunosuppressive effects are well-described, the immunological mechanisms modulated by dexamethasone in patients hospitalized ...
Job J. Engel, Caspar I. van der Made, Nick Keur, Todia Setiabudiawan, Rutger J. Röring, Georgia Damoraki, Helga Dijkstra, Heidi Lemmers, Sofia Ioannou, Garyfallia Poulakou, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar, Vinod Kumar, Frank L. van de Veerdonk, Mihai G. Netea, Mihai G. Netea, Athanasios Ziogas   +17 more
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Mouse B2 SINE elements function as IFN-inducible enhancers

eLife, 2023
Regulatory networks underlying innate immunity continually face selective pressures to adapt to new and evolving pathogens. Transposable elements (TEs) can affect immune gene expression as a source of inducible regulatory elements, but the significance ...
Isabella Horton, Conor J Kelly, Adam Dziulko, David M Simpson, Edward B Chuong   +4 more
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Interaction between chicken TRIM25 and MDA5 and their role in mediated antiviral activity against IBDV infection

Frontiers in Microbiology, 2022
Infectious Bursal Disease Virus (IBDV) is the causative agent of an immunosuppressive disease that affects domestic chickens (Gallus gallus) severely affecting poultry industry worldwide. IBDV infection is characterized by a rapid depletion of the bursal
Elisabet Diaz-Beneitez, Liliana Lilibeth Cubas-Gaona, Oscar Candelas-Rivera, Ana Benito-Zafra, Maria Teresa Sánchez-Aparicio, Maria Teresa Sánchez-Aparicio, Lisa Miorin, Lisa Miorin, José F. Rodríguez, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Dolores Rodríguez   +14 more
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Antiviral response within different cell types of the CNS

Frontiers in Immunology, 2022
The central nervous system (CNS) is a constitutive structure of various cell types conserved by anatomical barriers. Many of the major CNS cell-type populations distributed across the different brain regions are targets for several neurotropic viruses ...
Zahra Telikani, Ebony A. Monson, Markus J. Hofer, Karla J. Helbig   +3 more
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SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps

Frontiers in Immunology, 2022
Efficient HIV-1 replication depends on balanced levels of host cell components including cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1–10).
Helene Sertznig, Fabian Roesmann, Alexander Wilhelm, Delia Heininger, Barbara Bleekmann, Carina Elsner, Mario Santiago, Jonas Schuhenn, Zehra Karakoese, Yvonne Benatzy, Ryan Snodgrass, Stefan Esser, Kathrin Sutter, Ulf Dittmer, Marek Widera, Marek Widera   +15 more
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Dynamic changes of the proportion of HLA-DR and CD38 coexpression subsets on T lymphocytes during IFN-based chronic hepatitis B treatment

Frontiers in Immunology, 2023
BackgroundTo investigate the changes of human leukocyte antigen DR (HLA-DR) and CD38 coexpression subsets on T lymphocytes following interferon (IFN) therapy for those who have chronic hepatitis B (CHB).MethodsA prospective cohort of CHB patients ...
Yanjie Lin, Ge Shen, Si Xie, Xiaoyue Bi, Huihui Lu, Liu Yang, Tingting Jiang, Wen Deng, Shiyu Wang, Lu Zhang, Yao Lu, Yuanjiao Gao, Hongxiao Hao, Shuling Wu, Ruyu Liu, Min Chang, Mengjiao Xu, Leiping Hu, Xiaoxue Chen, Ronghai Huang, Minghui Li, Minghui Li, Yao Xie, Yao Xie   +23 more
doaj   +1 more source