Results 31 to 40 of about 607,302 (313)

Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]

, 2009
Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul, Johannsen, Eric, Haas, Juergen, Hyun Joo, Chul, Fossum, Even, Hutt-Fletcher, Lindsay M., Wu, L., Inn, Kyung-Soo, Jung, Jae U.   +8 more
core   +1 more source

Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis [PDF]

, 2012
Contains fulltext : 108027.pdf (Publisher’s version ) (Open Access)Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains the leading cause of mortality from a single infectious agent.
Crevel, R. van, van Crevel, R., Hazel E E Wong, Sahiratmadja Edhyana, Zhang, M.M., Wong, Hazel EE, Ottenhoff, THM, van de Vosse, Esther, Yang, N., Ottenhoff, T.H., Martin L Hibberd, Ottenhoff Tom H. M., Khor C.C., Dass, Ranjeeta, Reinout van Crevel, Hibberd M.L., van Crevel Reinout, Dass R.H., Yang, N, Chiea Chuen Khor, Khor, C.C., Seielstad, M., Zhang Mingzi M., van de Vosse E., Zhang M.M., Ottenhoff, Tom HM, Tom H M Ottenhoff, van Crevel, Reinout, Ottenhoff, T.H.M., Yang, Ninghan, Sahiratmadja, Edhyana, Wong, H.E., Seielstad M., Sahiratmadja E., Alisjahbana Bachti, Marzuki, Sangkot, van Crevel R., Khor, CC, Edhyana Sahiratmadja, Bachti Alisjahbana, Yang Ninghan, Alisjahbana, B., Hibberd, M.L., Ninghan Yang, Alisjahbana, Bachti, van, R, van de Vosse, E., Wong, Hazel, Dass Ranjeeta Hari, Alisjahbana, B, Ranjeeta Hari Dass, Hibberd, Martin, Yang, N.H., Sangkot Marzuki, Dass, Ranjeeta Hari, Seielstad Mark, Khor Chiea Chuen, Ottenhoff, Tom, Marzuki, S., Dass, RH, Hibberd Martin L., Marzuki, S, Wong H.E.E., Marzuki S., Zhang, M.Z.M., Zhang, MM, Khor, Chiea, van de Vosse Esther, Khor, Chiea Chuen, Mark Seielstad, Vosse, E. van de, Marzuki Sangkot, Sahiratmadja, E., Dass, R.H., Yang N., Zhang, Mingzi, Seielstad, Mark, Wong, HEE, Hibberd, Martin L, Sahiratmadja, E, Ottenhoff T.H.M., Zhang, Mingzi M, Esther van de Vosse, Alisjahbana B., Wong Hazel E. E., Wong, H.E.E., Mingzi M Zhang   +86 more
core   +1 more source

Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus

Frontiers in Immunology, 2022
Plasmacytoid dendritic cells [pDCs] represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons.
Mustafa H. Ghanem, Mustafa H. Ghanem, Andrew J. Shih, Houman Khalili, Emily G. Werth, Jayanta K. Chakrabarty, Lewis M. Brown, Kim R. Simpfendorfer, Kim R. Simpfendorfer, Peter K. Gregersen, Peter K. Gregersen   +10 more
doaj   +1 more source

Evolution of Interferons and Interferon Receptors [PDF]

Frontiers in Immunology, 2017
The earliest jawed vertebrates (Gnathostomes) would likely have had interferon (IFN) genes, since they are present in extant cartilaginous fish (sharks and rays) and bony fish (lobe-finned and ray-finned fish, the latter consisting of the chondrostei, holostei, and teleostei), as well as in tetrapods.
Secombes, Christopher John, Zou, Jun
openaire   +3 more sources

Interferon-producing cells are enriched for defective influenza segments.

, 2021
(A) Differential gene expression analysis on interferon-enriched and -depleted populations. An A549 type I interferon reporter cell line was infected at an MOI of 0.1 and sorted using magnetic-activated cell sorting 14 hours post infection.
Marisa Mendes (11820361), Alistair B. Russell (11820364)   +1 more
core   +1 more source

Peripheral Vasculitis, Intermediate Uveitis and Interferon Use in Multiple Sclerosis

Türk Oftalmoloji Dergisi, 2016
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. A 40-year-old female patient with a 12-year history of MS was admitted to our clinic with blurred vision and floaters in her right eye for about 1 ...
Haluk Esgin
doaj   +1 more source

Successful treatment of hairy cell leukaemia with pegylated interferon-alpha-2A

Pathology and Oncology Research
IntroductionHairy cell leukemia (HCL) is an indolent B-cell lymphoproliferative disease. Interferon-alpha (IFN-alpha) was the first successfully used drug in HCL; its favourable effect has been known since the early 1980s.
Kata Ferenczi, Zsófia Flóra Nagy, Ildikó Istenes, Hanna Eid, Csaba Bödör, Botond Timár, Judit Demeter   +6 more
doaj   +1 more source

Differential type I and type III interferon expression profiles in rheumatoid and juvenile idiopathic arthritis

Frontiers in Medicine
BackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood.
Anikó E. Malik, Anikó E. Malik, Drew Slauenwhite, Drew Slauenwhite, Sarah M. McAlpine, Sarah M. McAlpine, John G. Hanly, John G. Hanly, Jean S. Marshall, Beáta Dérfalvi, Beáta Dérfalvi, Thomas B. Issekutz, Thomas B. Issekutz   +12 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source