Results 31 to 40 of about 675,714 (307)

Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a. [PDF]

, 2004
S100B belongs to a family of calcium-binding proteins implicated in intracellular and extracellular regulatory activities. This study of serum S100B in primary progressive multiple sclerosis (PPMS) is based on data obtained from a randomized, controlled ...
Lim, Ee Tuan, Leary, Siobhan M, Geoff Keir, Petzold, Axel, Thompson, Alan J, Gavin Giovannoni, Siobhan M Leary, Altmann, Daniel R, Keir, Geoff, Ee Tuan Lim, David H Miller, Ed J Thompson, Giovannoni, Gavin, Miller, David H, Alan J Thompson, Daniel R Altmann, Thompson, Ed J, Axel Petzold   +17 more
core   +2 more sources

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses

Frontiers in Immunology, 2018
Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as γ-activated factor (GAF)
Agata Michalska, Katarzyna Blaszczyk, Joanna Wesoly, Hans A. R. Bluyssen   +3 more
doaj   +1 more source

Dynamics of Transforming Growth Factor (TGF)-β Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines

Frontiers in Immunology, 2020
Human immunodeficiency virus type 1 (HIV-1) infection triggers rapid induction of multiple innate cytokines including type I interferons, which play important roles in viral control and disease pathogenesis.
Matthew Dickinson, Matthew Dickinson, Anna E. Kliszczak, Eleni Giannoulatou, Eleni Giannoulatou, Dimitra Peppa, Dimitra Peppa, Pierre Pellegrino, Ian Williams, Hal Drakesmith, Persephone Borrow   +10 more
doaj   +1 more source

Virus Infections and Host Metabolism—Can We Manage the Interactions?

Frontiers in Immunology, 2021
When viruses infect cells, they almost invariably cause metabolic changes in the infected cell as well as in several host cell types that react to the infection.
Deepak Sumbria, Engin Berber, Engin Berber, Manikannan Mathayan, Barry T. Rouse   +4 more
doaj   +1 more source

Bunyaviruses and the type I interferon system [PDF]

, 2009
The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Weber, F., Richard Elliott, Elliott, Richard Michael, Friedemann Weber, Weber, F, Elliott, R.M.   +6 more
core   +1 more source

Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection

Cell Reports Medicine, 2020
Summary: Lung transplantation can be lifesaving in end-stage cystic fibrosis (CF), but long-term survival is limited by chronic lung allograft dysfunction (CLAD).
Daniel T. Dugger, Monica Fung, Lorna Zlock, Saharai Caldera, Louis Sharp, Steven R. Hays, Jonathan P. Singer, Lorriana E. Leard, Jefferey A. Golden, Rupal J. Shah, Jasleen Kukreja, Erin Gordon, Walter Finkbeiner, Mary Ellen Kleinhenz, Chaz Langelier, John R. Greenland   +15 more
doaj   +1 more source

Interferon-α action in cytokine profile in eosinophilic nasal polyp cultures

, 2021
Introduction Chronic rhinosinusitis is currently classified into two types: chronic rhinosinusitis without nasal polyps and chronic rhinosinusitis with nasal polyps.
Júlio Cláudio Sousa (12651722), Eddie Fernando Cândido Murta (12651734), Márcia Antoniazi Michelin (12651737), Renata Margarida Etchbehere (12651725), Letícia Montes Stark (12651731), Eduardo Arthur Rodovalho Alves (12651728)   +5 more
core   +1 more source

Influenza virus activation of the interferon system [PDF]

, 2015
This study was supported by the Wellcome Trust (grant number 087751/A/08/Z) and the Medical Research Council (grant number G0700848).The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to ...
Fodor, E., Killip, M.J., Randall, R.E., Randall, R.E.; id_orcid   +3 more
core   +1 more source

An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response [PDF]

, 2014
Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG I-dependent activation of interferon (IFN) transcription, IFN-dependent upregulation of IFN-stimulated genes (ISGs) and the activity of various ...
Fernández, Yolanda, Oliveros, JC, Randall, Richard E, Asensio, Víctor J, Killip, Marian J., Randall, RE, Oliveros, Juan Carlos, Killip, Marian J, Asensio, Víctor J., Bengoechea, Jose Antonio, Oliveros, Juan C., Pérez-Cidoncha, Maite, Pérez-Cidoncha, M, Bengoechea, JA, Bengoechea, José A; id_orcid, Ortín, Juan, Killip, MJ, Ortín, J, Asensio, Víctor José, Randall, Richard E., Bengoechea, José A., Asensio, VJ, Oliveros, Juan C, Fernández, Y, Randall, Richard E.; id_orcid   +24 more
core   +1 more source

Generation of replication-proficient Influenza Virus NS1 point mutants with interferon-hyperinducer phenotype [PDF]

, 2014
The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN.
Fernández, Yolanda, Juan Ortín, Randall, Richard E, Richard E. Randall (190211), Killip, Marian J, Víctor J Asensio, Bengoechea, José A, Pérez-Cidoncha, M, Marian J. Killip (571160), Marian J Killip, Maite Pérez-Cidoncha (195699), Ortín, Juan, Killip, MJ, Ortín, J, Richard E Randall, Juan Ortín (5649007), Yolanda Fernández, Fernández, Y, Asensio, Víctor J, Randall, RE, José A Bengoechea, José A. Bengoechea (124595), Pérez-Cidoncha, Maite, Bengoechea, JA, Víctor J. Asensio (571161), Bengoechea, José A; id_orcid, Maite Pérez-Cidoncha, Asensio, VJ, Yolanda Fernández (268684), Bengoechea, Jose Antonio, Asensio, Víctor José, Randall, Richard E., Asensio Víctor J., Pérez-Cidoncha Maite, Randall Richard E., Ortín Juan, Fernández Yolanda, Bengoechea José A., Killip Marian J., Randall, Richard E; id_orcid   +39 more
core   +2 more sources