‘It’s been a long haul, a big haul, but we’ve made it’: hepatitis C virus treatment in post-transplant patients with virus recurrence: An interpretative phenomenological analysis [PDF]
, 2018 The lived experience of both interferon-based and new interferon-free treatments in patients with hepatitis C virus remains understudied. To explore their journey through hepatitis C virus treatment, we interviewed seven post-transplant patients with ...
Chouliara, Zoe +4 more
core +3 more sources
Hepatitis C virus genotypes in liver transplant recipients: Impact on posttransplant recurrence, infections, response to interferon-α therapy and outcome [PDF]
, 1997 Background. End-stage liver disease due to hepatitis C virus (HCV) is the most common indication for liver transplantation in U.S. veterans. We investigated the influence of HCV genotypes on the incidence and timing of recurrent HCV hepatitis, survival ...
Fung, JJ +10 more
core +1 more source
Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy
Frontiers in Oncology, 2021 Cancers, including lymphomas, develop in complex tissue environments where malignant cells actively promote the creation of a pro-tumoral niche that suppresses effective anti-tumor effector T cell responses.
Benedetta Apollonio +3 more
doaj +1 more source
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice [PDF]
, 2013 The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence of resolution, inflammatory pathologies can emerge, resulting in substantial morbidity and mortality.
Baldwin, H.M. +9 more
core +1 more source
Frontiers in Immunology, 2022 Plasmacytoid dendritic cells [pDCs] represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons.
Mustafa H. Ghanem +10 more
doaj +1 more source
The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]
, 2018 The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S +6 more
core +2 more sources
Peripheral Vasculitis, Intermediate Uveitis and Interferon Use in Multiple Sclerosis
Türk Oftalmoloji Dergisi, 2016 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. A 40-year-old female patient with a 12-year history of MS was admitted to our clinic with blurred vision and floaters in her right eye for about 1 ...
Haluk Esgin
doaj +1 more source
A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]
, 2019 Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y. +2 more
core +1 more source
An expert consensus for the management of chronic hepatitis B in Asian Americans. [PDF]
, 2018 BACKGROUND: Hepatitis B virus (HBV) infection is common with major clinical consequences. In Asian Americans, the HBsAg carrier rate ranges from 2% to 16% which approximates the rates from their countries of origin.
Abbas +173 more
core +2 more sources