Results 21 to 30 of about 675,714 (307)
Frontiers in Immunology, 2023 Interferons (IFNs), IFN-stimulated genes (ISGs), and inflammatory cytokines mediate innate immune responses, and are essential to establish an antiviral response.
Laura Villamayor +6 more
doaj +1 more source
Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands [PDF]
, 1992 Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a ...
Pavic, Ivica +5 more
core +2 more sources
Transcriptional responses of tumor cell lines to interferon-alpha [PDF]
, 2013 Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core +1 more source
Oromucosal Administration of Interferon to Humans
Pharmaceuticals, 2010 The prevailing dogma is that, to be systemically effective, interferon-alpha (IFNα) must be administered in sufficiently high doses to yield functional blood concentrations.
Manfred W. Beilharz +3 more
doaj +1 more source
The use of interferon in medicine
Journal of Education, Health and Sport, 2020 Interferons are low-molecular weight glycoproteins. They are characterized by paracrine and autocrine activity. Their production and release occurs through various types of cells, which ultimately leads to the protection of the body against viral ...
Waldemar Pluta +2 more
doaj +1 more source
Interferon signalling in the liver : implications for the natural course and therapy of hepatitis C [PDF]
, 2012 Hepatitis C virus is a global health concern, estimated to infect 2-3% of the world's population. Inter-individual differences in the course of infection and response to therapy, highlighted by recent genomewide association studies, point to the crucial ...
Makowska, Zuzanna
core +1 more source
Interferon-producing cells are enriched for defective influenza segments.
, 2021 (A) Differential gene expression analysis on interferon-enriched and -depleted populations. An A549 type I interferon reporter cell line was infected at an MOI of 0.1 and sorted using magnetic-activated cell sorting 14 hours post infection.
Marisa Mendes (11820361) +1 more
core +1 more source
Viruses, 2019 The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their cognate receptor and activate the Janus Kinase/Signal Transducer ...
Caroline L. Ashley +3 more
doaj +1 more source
Journal of Applied Hematology, 2020 BACKGROUND: Although tyrosine kinase inhibitors (TKIs) are the gold standard in clinical management of chronic myeloid leukemia, it is not feasible to use these drugs in at least some cases when patients are resistance to all available TKIs due to ...
Zafar Iqbal +12 more
doaj +1 more source
Frontiers in Immunology, 2021 The intestine can be the target of several immunologically mediated diseases, including graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD).
Eileen Haring +5 more
doaj +1 more source