Results 21 to 30 of about 492,253 (263)

Oral Supplementation of Houttuynia cordata Extract Reduces Viremia in PRRSV-1 Modified-Live Virus-Vaccinated Pigs in Response to the HP-PRRSV-2 Challenge

Frontiers in Immunology, 2022
This study evaluated the in vitro antiviral activities and the ex vivo immunomodulatory effects of Houttuynia cordata Thunb. (HC) ethanolic extracts in response to porcine reproductive and respiratory syndrome virus (PRRSV).
Wilawan Ruansit, Wasin Charerntantanakul
doaj   +1 more source

Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model

Frontiers in Immunology, 2018
DDX41 is an important sensor for host recognition of DNA viruses and initiation of nuclear factor-κB (NF-κB) and IFN signaling pathways in mammals. However, its occurrence and functions in other vertebrates remain poorly defined.
Jun-xia Ma, Jiang-yuan Li, Dong-dong Fan, Wei Feng, Ai-fu Lin, Li-xin Xiang, Jian-zhong Shao, Jian-zhong Shao   +7 more
doaj   +1 more source

The novel immunobiotic Clostridium butyricum S-45-5 displays broad-spectrum antiviral activity in vitro and in vivo by inducing immune modulation

Frontiers in Immunology, 2023
Clostridium butyricum is known as a probiotic butyric acid bacterium that can improve the intestinal environment. In this study, we isolated a new strain of C.
Kiramage Chathuranga, Yeseul Shin, Md Bashir Uddin, Md Bashir Uddin, Md Bashir Uddin, Jayoung Paek, W. A. Gayan Chathuranga, Yebin Seong, Lu Bai, Hongik Kim, Jeong Hwan Shin, Young-Hyo Chang, Jong-Soo Lee   +12 more
doaj   +1 more source

In-Cell Western Assays to Evaluate Hantaan Virus Replication as a Novel Approach to Screen Antiviral Molecules and Detect Neutralizing Antibody Titers

Frontiers in Cellular and Infection Microbiology, 2017
Hantaviruses encompass rodent-borne zoonotic pathogens that cause severe hemorrhagic fever disease with high mortality rates in humans. Detection of infectious virus titer lays a solid foundation for virology and immunology researches.
Hong-Wei Ma, Wei Ye, He-Song Chen, Tie-Jian Nie, Lin-Feng Cheng, Liang Zhang, Pei-Jun Han, Xing-An Wu, Zhi-Kai Xu, Ying-Feng Lei, Fang-Lin Zhang   +10 more
doaj   +1 more source

Interferonogenic activity of the strain BH-3 duck hepatitis virus type I (Picornaviridae: Avihepatovirus: Avihepatovirus A)

Вопросы вирусологии, 2021
Introduction. Duck viral hepatitis type I (DVH-I) is a poorly studied contagious disease caused by RNA-containing duck (Anatinae) hepatitis virus type I (Picornaviridae: Avihepatovirus: Avihepatovirus A).
N. V. Nikitina, I. K. Leonov, L. I. Yavdoshak   +2 more
doaj   +1 more source

Antiviral Immune Response in Alzheimer’s Disease: Connecting the Dots

Frontiers in Neuroscience, 2020
Alzheimer’s disease (AD) represents an enormous public health challenge currently and with increasing urgency in the coming decades. Our understanding of the etiology and pathogenesis of AD is rather incomplete, which is manifested in stagnated ...
Ethan R. Roy, Wei Cao
doaj   +1 more source

Evolution of Interferons and Interferon Receptors [PDF]

Frontiers in Immunology, 2017
The earliest jawed vertebrates (Gnathostomes) would likely have had interferon (IFN) genes, since they are present in extant cartilaginous fish (sharks and rays) and bony fish (lobe-finned and ray-finned fish, the latter consisting of the chondrostei, holostei, and teleostei), as well as in tetrapods.
Secombes, Christopher John, Zou, Jun
openaire   +3 more sources

Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses

Cells, 2021
Host cell-intrinsic antiviral responses are largely mediated by pattern-recognition receptor (PRR) signaling and the interferon (IFN) system. The IFN regulatory factor (IRF) family of transcription factors takes up a central role in transcriptional ...
Sandra Wüst, Paulina Schad, Sandy Burkart, Marco Binder   +3 more
doaj   +1 more source

Mayaro Virus Non-Structural Protein 2 Circumvents the Induction of Interferon in Part by Depleting Host Transcription Initiation Factor IIE Subunit 2

Cells, 2021
Mayaro virus (MAYV) is an emerging mosquito-transmitted virus that belongs to the genus Alphavirus within the family Togaviridae. Humans infected with MAYV often develop chronic and debilitating arthralgia and myalgia.
Ray Ishida, Jamie Cole, Joaquin Lopez-Orozco, Nawell Fayad, Alberto Felix-Lopez, Mohamed Elaish, Shu Yue Luo, Olivier Julien, Anil Kumar, Tom C. Hobman   +9 more
doaj   +1 more source

Host Cell Restriction Factors of Bunyaviruses and Viral Countermeasures

Viruses, 2021
The Bunyavirales order comprises more than 500 viruses (generally defined as bunyaviruses) classified into 12 families. Some of these are highly pathogenic viruses infecting different hosts, including humans, mammals, reptiles, arthropods, birds, and/or ...
Solène Lerolle, Natalia Freitas, François-Loïc Cosset, Vincent Legros   +3 more
doaj   +1 more source