Results 21 to 30 of about 656,599 (299)

Dynamic changes of the proportion of HLA-DR and CD38 coexpression subsets on T lymphocytes during IFN-based chronic hepatitis B treatment

Frontiers in Immunology, 2023
BackgroundTo investigate the changes of human leukocyte antigen DR (HLA-DR) and CD38 coexpression subsets on T lymphocytes following interferon (IFN) therapy for those who have chronic hepatitis B (CHB).MethodsA prospective cohort of CHB patients ...
Yanjie Lin, Ge Shen, Si Xie, Xiaoyue Bi, Huihui Lu, Liu Yang, Tingting Jiang, Wen Deng, Shiyu Wang, Lu Zhang, Yao Lu, Yuanjiao Gao, Hongxiao Hao, Shuling Wu, Ruyu Liu, Min Chang, Mengjiao Xu, Leiping Hu, Xiaoxue Chen, Ronghai Huang, Minghui Li, Minghui Li, Yao Xie, Yao Xie   +23 more
doaj   +1 more source

Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation

Frontiers in Immunology, 2023
Interferons (IFNs), IFN-stimulated genes (ISGs), and inflammatory cytokines mediate innate immune responses, and are essential to establish an antiviral response.
Laura Villamayor, Vanessa Rivero, Darío López-García, David J. Topham, Luis Martínez-Sobrido, Aitor Nogales, Marta L. DeDiego   +6 more
doaj   +1 more source

Transcriptional responses of tumor cell lines to interferon-alpha [PDF]

, 2013
Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core   +1 more source

Oromucosal Administration of Interferon to Humans

Pharmaceuticals, 2010
The prevailing dogma is that, to be systemically effective, interferon-alpha (IFNα) must be administered in sufficiently high doses to yield functional blood concentrations.
Manfred W. Beilharz, Joseph M. Cummins, Martin J. Cummins, Alayne L. Bennett   +3 more
doaj   +1 more source

The use of interferon in medicine

Journal of Education, Health and Sport, 2020
Interferons are low-molecular weight glycoproteins. They are characterized by paracrine and autocrine activity. Their production and release occurs through various types of cells, which ultimately leads to the protection of the body against viral ...
Waldemar Pluta, Wioleta Dudzińska, Anna Lubkowska   +2 more
doaj   +1 more source

Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a. [PDF]

, 2004
S100B belongs to a family of calcium-binding proteins implicated in intracellular and extracellular regulatory activities. This study of serum S100B in primary progressive multiple sclerosis (PPMS) is based on data obtained from a randomized, controlled ...
Lim, Ee Tuan, Leary, Siobhan M, Geoff Keir, Petzold, Axel, Thompson, Alan J, Gavin Giovannoni, Siobhan M Leary, Altmann, Daniel R, Keir, Geoff, Ee Tuan Lim, David H Miller, Ed J Thompson, Giovannoni, Gavin, Miller, David H, Alan J Thompson, Daniel R Altmann, Thompson, Ed J, Axel Petzold   +17 more
core   +2 more sources

Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression

Viruses, 2019
The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their cognate receptor and activate the Janus Kinase/Signal Transducer ...
Caroline L. Ashley, Allison Abendroth, Brian P. McSharry, Barry Slobedman   +3 more
doaj   +1 more source

Eradication of prior-to-treatment compound BCR-ABL mutations by interferon-alpha in chronic myeloid leukemia: Long-term follow-up studies and review of literature

Journal of Applied Hematology, 2020
BACKGROUND: Although tyrosine kinase inhibitors (TKIs) are the gold standard in clinical management of chronic myeloid leukemia, it is not feasible to use these drugs in at least some cases when patients are resistance to all available TKIs due to ...
Zafar Iqbal, Tanveer Akhtar, Ahmad M Khalid, Aamer Aleem, Amer Mahmood, Afia M Akram, Mahmood Rasool, Ijaz H Shah, Aysha Bhalli, Muhammad Khalid, Mudassar Iqbal, Abid Jameel, Nawaf Al-Anazi   +12 more
doaj   +1 more source

Interfering With Inflammation: Heterogeneous Effects of Interferons in Graft-Versus-Host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease

Frontiers in Immunology, 2021
The intestine can be the target of several immunologically mediated diseases, including graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD).
Eileen Haring, Eileen Haring, Robert Zeiser, Robert Zeiser, Petya Apostolova, Petya Apostolova   +5 more
doaj   +1 more source

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses

Frontiers in Immunology, 2018
Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as γ-activated factor (GAF)
Agata Michalska, Katarzyna Blaszczyk, Joanna Wesoly, Hans A. R. Bluyssen   +3 more
doaj   +1 more source