Results 11 to 20 of about 492,253 (263)

Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation

Frontiers in Immunology, 2023
Interferons (IFNs), IFN-stimulated genes (ISGs), and inflammatory cytokines mediate innate immune responses, and are essential to establish an antiviral response.
Laura Villamayor, Vanessa Rivero, Darío López-García, David J. Topham, Luis Martínez-Sobrido, Aitor Nogales, Marta L. DeDiego   +6 more
doaj   +1 more source

Oromucosal Administration of Interferon to Humans

Pharmaceuticals, 2010
The prevailing dogma is that, to be systemically effective, interferon-alpha (IFNα) must be administered in sufficiently high doses to yield functional blood concentrations.
Manfred W. Beilharz, Joseph M. Cummins, Martin J. Cummins, Alayne L. Bennett   +3 more
doaj   +1 more source

The use of interferon in medicine

Journal of Education, Health and Sport, 2020
Interferons are low-molecular weight glycoproteins. They are characterized by paracrine and autocrine activity. Their production and release occurs through various types of cells, which ultimately leads to the protection of the body against viral ...
Waldemar Pluta, Wioleta Dudzińska, Anna Lubkowska   +2 more
doaj   +1 more source

Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression

Viruses, 2019
The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their cognate receptor and activate the Janus Kinase/Signal Transducer ...
Caroline L. Ashley, Allison Abendroth, Brian P. McSharry, Barry Slobedman   +3 more
doaj   +1 more source

Eradication of prior-to-treatment compound BCR-ABL mutations by interferon-alpha in chronic myeloid leukemia: Long-term follow-up studies and review of literature

Journal of Applied Hematology, 2020
BACKGROUND: Although tyrosine kinase inhibitors (TKIs) are the gold standard in clinical management of chronic myeloid leukemia, it is not feasible to use these drugs in at least some cases when patients are resistance to all available TKIs due to ...
Zafar Iqbal, Tanveer Akhtar, Ahmad M Khalid, Aamer Aleem, Amer Mahmood, Afia M Akram, Mahmood Rasool, Ijaz H Shah, Aysha Bhalli, Muhammad Khalid, Mudassar Iqbal, Abid Jameel, Nawaf Al-Anazi   +12 more
doaj   +1 more source

Interfering With Inflammation: Heterogeneous Effects of Interferons in Graft-Versus-Host Disease of the Gastrointestinal Tract and Inflammatory Bowel Disease

Frontiers in Immunology, 2021
The intestine can be the target of several immunologically mediated diseases, including graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD).
Eileen Haring, Eileen Haring, Robert Zeiser, Robert Zeiser, Petya Apostolova, Petya Apostolova   +5 more
doaj   +1 more source

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses

Frontiers in Immunology, 2018
Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as γ-activated factor (GAF)
Agata Michalska, Katarzyna Blaszczyk, Joanna Wesoly, Hans A. R. Bluyssen   +3 more
doaj   +1 more source

Dynamics of Transforming Growth Factor (TGF)-β Superfamily Cytokine Induction During HIV-1 Infection Are Distinct From Other Innate Cytokines

Frontiers in Immunology, 2020
Human immunodeficiency virus type 1 (HIV-1) infection triggers rapid induction of multiple innate cytokines including type I interferons, which play important roles in viral control and disease pathogenesis.
Matthew Dickinson, Matthew Dickinson, Anna E. Kliszczak, Eleni Giannoulatou, Eleni Giannoulatou, Dimitra Peppa, Dimitra Peppa, Pierre Pellegrino, Ian Williams, Hal Drakesmith, Persephone Borrow   +10 more
doaj   +1 more source

Virus Infections and Host Metabolism—Can We Manage the Interactions?

Frontiers in Immunology, 2021
When viruses infect cells, they almost invariably cause metabolic changes in the infected cell as well as in several host cell types that react to the infection.
Deepak Sumbria, Engin Berber, Engin Berber, Manikannan Mathayan, Barry T. Rouse   +4 more
doaj   +1 more source

Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection

Cell Reports Medicine, 2020
Summary: Lung transplantation can be lifesaving in end-stage cystic fibrosis (CF), but long-term survival is limited by chronic lung allograft dysfunction (CLAD).
Daniel T. Dugger, Monica Fung, Lorna Zlock, Saharai Caldera, Louis Sharp, Steven R. Hays, Jonathan P. Singer, Lorriana E. Leard, Jefferey A. Golden, Rupal J. Shah, Jasleen Kukreja, Erin Gordon, Walter Finkbeiner, Mary Ellen Kleinhenz, Chaz Langelier, John R. Greenland   +15 more
doaj   +1 more source