Results 11 to 20 of about 607,302 (313)

Antivirals against HCV infection: the story thus far

Journal of Infection in Developing Countries, 2022
Remarkable scientific breakthroughs have been made in the stride towards the development of potent and tolerable hepatitis C regimens within the last three decades.
Ahmad Adebayo Irekeola, Engku Nur Syafirah EAR, Nur Amalin Zahirah Mohd Amin, Nazri Mustaffa, Rafidah Hanim Shueb   +4 more
doaj   +1 more source

Expression, purification, and bioactivity of a soluble recombinant ovine interferon-tau in Escherichia coli

Journal of Veterinary Research, 2021
Ovine interferon-tau (oIFN-τ) is a newly discovered type I interferon. This study used biochemical techniques to transform the oIFN-τ gene into Escherichia coli to obtain the mass and soluble expression of the recombinant protein.
Yu Hai-Yang, Gao Dong-Mei, Zhou Wei, Xia Bing-Bing, He Zhi-Yuan, Wu Bo, Jiang Min-Zhi, Wang Ming-Li, Zhao Jun   +8 more
doaj   +1 more source

Acute and sub-chronic toxicity study of recombinant bovine interferon alpha in rodents

Journal of Veterinary Research, 2021
Recombinant bovine interferon alpha (rBoIFN-α) has been demonstrated to have antiviral activity. However, no conduct of acute or chronic toxicity tests has been reported.
Yu Hai-Yang, Gao Dong-Mei, Zhou Wei, Xia Bing-Bing, He Zhi-Yuan, Wu Bo, Jiang Min-Zhi, Wang Ming-Li, Zhao Jun   +8 more
doaj   +1 more source

Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense

Biomolecules & Biomedicine, 2021
Coronavirus disease-19 (COVID-19) is an extremely infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has become a major global health concern.
Abualgasim Elgaili Abdalla , Jianping Xie, Kashaf Junaid, Sonia Younas, Tilal Elsaman, Khalid Omer Abdalla Abosalif, Ayman Ali Mohammed Alameen, Mahjoob Osman Mahjoob, Mohammed Yagoub Mohammed Elamir, Hasan Ejaz   +9 more
doaj   +1 more source

Grass Carp Reovirus VP35 Degrades MAVS Through the Autophagy Pathway to Inhibit Fish Interferon Production

Frontiers in Immunology, 2021
Fish interferon (IFN) is a crucial cytokine for a host to resist external pathogens, conferring cells with antiviral capacity. Meanwhile, grass carp reovirus (GCRV) is a strong pathogen that causes high mortality in grass carp. Therefore, it is necessary
Long-Feng Lu, Can Zhang, Can Zhang, Zhuo-Cong Li, Zhuo-Cong Li, Xiao-Yu Zhou, Xiao-Yu Zhou, Jing-Yu Jiang, Jing-Yu Jiang, Dandan Chen, Yong-An Zhang, Yong-An Zhang, Shun Li   +12 more
doaj   +1 more source

DEAD-Box RNA Helicase 21 (DDX21) Positively Regulates the Replication of Porcine Reproductive and Respiratory Syndrome Virus via Multiple Mechanisms

Viruses, 2022
The porcine reproductive and respiratory syndrome virus (PRRSV) remains a persistent hazard in the global pig industry. DEAD (Glu-Asp-Ala-Glu) box helicase 21 (DDX21) is a member of the DDX family.
Jia Li, Dang Wang, Puxian Fang, Yu Pang, Yanrong Zhou, Liurong Fang, Shaobo Xiao   +6 more
doaj   +1 more source

Transcriptional responses of tumor cell lines to interferon-alpha [PDF]

, 2013
Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core   +1 more source

Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a. [PDF]

, 2004
S100B belongs to a family of calcium-binding proteins implicated in intracellular and extracellular regulatory activities. This study of serum S100B in primary progressive multiple sclerosis (PPMS) is based on data obtained from a randomized, controlled ...
Lim, Ee Tuan, Leary, Siobhan M, Geoff Keir, Petzold, Axel, Thompson, Alan J, Gavin Giovannoni, Siobhan M Leary, Altmann, Daniel R, Keir, Geoff, Ee Tuan Lim, David H Miller, Ed J Thompson, Giovannoni, Gavin, Miller, David H, Alan J Thompson, Daniel R Altmann, Thompson, Ed J, Axel Petzold   +17 more
core   +1 more source

Pharmacotherapy of hepatitis D: the current and the future [PDF]

Exploration of Digestive Diseases
Hepatitis D virus (HDV), a satellite virus requiring hepatitis B surface antigen (HBsAg) for propagation, is a hepatotropic virus implicated in acute and chronic viral hepatitis, with an accentuated risk of cirrhosis and hepatocellular carcinoma.
George Sarin Zacharia, Anu Jacob
doaj   +1 more source

Impaired Antiviral Responses to Extracellular Double-Stranded RNA and Cytosolic DNA, but Not to Interferon-α Stimulation, in TRIM56-Deficient Cells

Viruses, 2022
The physiologic function of tripartite motif protein 56 (TRIM56), a ubiquitously expressed E3 ligase classified within the large TRIM protein family, remains elusive.
Dang Wang, Ruixue Wang, Kui Li
doaj   +1 more source