Results 221 to 230 of about 104,312 (252)

Multi-Soliton Microcombs Enable Ultrafast Nanometric-Precision Ranging and Photon-Level Detection. [PDF]

Adv Sci (Weinh)
Zhi J, Guo X, Yang X, Little BE, Chu ST, Shao C, Wang M, Liang Y, Xie P, Wang W, Wu H.   +10 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Repurposed small-molecule inhibitors of Plasmodium falciparum calmodulins disrupt calcium homeostasis. [PDF]

Int J Parasitol Drugs Drug Resist
Tammour A, Parveen S, Panda A, Ahmad S, Abbas M, Madhav H, Khan Z, Thalor A, Rath PP, Prakash N, Junaid IT, Mukhtar O, Gupta D, Mohmmed A, Malhotra P.   +14 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

A bacterial protein inhibitor of dUTPase disrupts zebrafish embryogenesis through a conserved active-site mechanism. [PDF]

Protein Sci
Perey-Simon V, Tóth ZS, Dombovári D, Kazzazy L, Varga M, Vértessy BG, Nagy GN, Nyíri K.   +7 more
europepmc   +1 more source

Generic generation and manipulation of high-dimensional spin-orbit states in Hilbert space. [PDF]

Nat Commun
Li P, Zhao R, Cui Y, Geng G, Li J, Ren X, Wu Y, Wang Y, Zhang S, Huang L.   +9 more
europepmc   +1 more source

Identification of Two Competition-Defined Neutralizing Antibody Groups Targeting the HHV-6B gH/gL/gQ1/gQ2 Complex Independent of CD134 Binding. [PDF]

Microbiol Immunol
Putra AJE, Dharmika IAGW, Hasegawa N, Gunawan RR, Takamiya R, Nishimura M, Mori Y.   +6 more
europepmc   +1 more source

Measurement of ion acceleration and diffusion in a laser-driven magnetized plasma. [PDF]

Nat Commun
Chu JTY, Halliday JWD, Heaton C, Moczulski K, Blazevic A, Schumacher D, Metternich M, Nazary H, Arrowsmith CD, Bell AR, Beyer KA, Bott AFA, Campbell T, Hansen E, Lamb DQ, Miniati F, Neumayer P, Palmer CAJ, Reville B, Reyes A, Sarkar S, Scopatz A, Spindloe C, Stuart CB, Wen H, Tzeferacos P, Bingham R, Gregori G.   +27 more
europepmc   +1 more source

Tear Film Imager Findings Support a New Perspective on the Mechanisms of Tear Film Thinning in Healthy Subjects. [PDF]

Invest Ophthalmol Vis Sci
Sun MM, Beniga C, Zheng S, Gladstein S, López FJ, Xu X, Nguyen A, Robinson MR.   +7 more
europepmc   +1 more source

Multi-Wavelength Interferometric Absolute Distance Measurement and Dynamic Demodulation Error Compensation. [PDF]

Sensors (Basel)
Fang J, Ou C, Liu F, Wu Y.
europepmc   +1 more source