Results 71 to 80 of about 27,952 (237)

Lab‐Scale Continuous Biomanufacturing: A Tool for Process Development With Adaptive Strategies for Capture and Virus Inactivation

open access: yesBiotechnology and Bioengineering, EarlyView.
Schematic representation of the continuous lab‐scale process. ABSTRACT Monoclonal antibodies (mAbs) are nowadays fundamental in treating a wide range of severe diseases, including cancer, infections, or autoimmune disorders. Due to their high specificity, potent activity, and fewer side effects compared to small molecular drugs, the market for mAbs is ...
Thomas Kruse   +5 more
wiley   +1 more source

Interference Measurements Across Vacuum and Atmospheric Environments for Characterization of Space-Borne Telescope

open access: yesPhotonics
A space-borne telescope is used for Earth observation at about 500 km above sea level in the thermosphere where the air density is very low and the temperature increases significantly during daytime. If the telescopes are aligned and characterized on the
Yi-Kai Huang, Cheng-Huan Chen
doaj   +1 more source

SURE-Fuse WFF: A Multi-Resolution Windowed Fourier Analysis for Interferometric Phase Denoising

open access: yesIEEE Access, 2019
Interferometric phase (InPhase) images, acquired by phase imaging systems, often suffer from two major degradations: 1) phase wrapping, caused by the sinusoidal 2π-periodic sensing mechanism, and 2) noise, introduced by the acquisition process or ...
Joshin P. Krishnan   +2 more
doaj   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier   +3 more
wiley   +1 more source

Interferometry of ionospheric E-region irregularities based on Kunming VHF radars

open access: yesFrontiers in Astronomy and Space Sciences
There is a long history of using VHF radar systems to detect ionospheric irregularities based on the theory of coherent scattering. According to previous work, there is a high occurrence of field-aligned irregularities (FAIs) in the ionospheric E-region ...
Bo Chen   +13 more
doaj   +1 more source

Measuring Coseismic Deformation With Spaceborne Synthetic Aperture Radar: A Review

open access: yesFrontiers in Earth Science, 2019
In the past 25 years, space-borne Synthetic Aperture Radar imagery has become an increasingly available data source for the study of crustal deformation associated with moderate to large earthquakes (M > 4.0).
John Peter Merryman Boncori
doaj   +1 more source

2D copper nanozyme patches facilitate bone regeneration via interfacial modulation of osteoclast‐osteoblast dynamics

open access: yesBMEMat, EarlyView.
This study develops a nano‐enzyme patch (ezPatch) targeting bone interfaces. Utilizing ligand‐to‐metal charge transfer (LMCT) catalysis and bone‐targeting ligands on copper nanosheets, ezPatch simultaneously scavenges reactive oxygen species (ROS) and generates oxygen in situ at bone‐losing sites.
Yi Chen   +12 more
wiley   +1 more source

Comparison of Molecular Iodine Spectral Properties at 514.7 and 532 nm Wavelengths

open access: yesMeasurement Science Review, 2014
We present results of investigation and comparison of spectral properties of molecular iodine transitions in the spectral region of 514.7 nm that are suitable for laser frequency stabilization and metrology of length.
Hrabina J.   +7 more
doaj   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

open access: yesBMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu   +13 more
wiley   +1 more source

A Tandem Chemical Vapor Deposition Platform for the Solvent‐Free Synthesis of Polypeptide Architectures

open access: yesChemistry – A European Journal, EarlyView.
A solvent‐free, two‐step chemical vapor polymerization enables efficient, substrate‐independent synthesis of surface‐attached polypeptide films. Initiator deposition via CVD is followed by NCA ring‐opening polymerization. Characterization confirms film formation and functionalization, allowing precise micropatterning and bioactive surface design for ...
Domenic Kratzer   +4 more
wiley   +1 more source

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