Results 141 to 150 of about 574,262 (313)

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Interferon signaling pathways in health and disease. [PDF]

Mol Biomed
Wen C, Lan Q, Wang Y, Ni Y, Wong AST, Liu D.   +5 more
europepmc   +1 more source

Figure S2 from Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients

Brooke Horowitch, Daniel Y. Lee, Min Ding, Sandra Martínez-Morilla, Thazin Nwe Aung, Feriel Ouerghi, Xueting Wang, Wei Wei, William Damsky, Mario Sznol, Harriet M. Kluger, David L. Rimm, Jeffrey J. Ishizuka   +12 more
openalex   +1 more source

Induction of Protein Kinase PKR-dependent Activation of Interferon Regulatory Factor 3 by Vaccinia Virus Occurs through Adapter IPS-1 Signaling [PDF]

, 2008
Ping Zhang, Charles E. Samuel
openalex   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

IGFBP-6 regulates breast cancer cell cycle progression by promoting exit out of G1. [PDF]

J Biol Chem
Lariz FJ, Hernandez S, Bautista-Tovar DC, Houston KD.   +3 more
europepmc   +1 more source

Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ [PDF]

, 1989
Ernst R. Werner, Gabriele Werner‐Felmayer, Dietmar Fuchs, Arno Hausen, Gilbert Reibnegger, H. Wächter   +5 more
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

STING agonists as antiviral agents. [PDF]

FEBS Lett
Nelson TS, Ma Z.
europepmc   +1 more source

Interferon‐α activates signal transducers and activators of transcription 5 and 6 in Daudi cells [PDF]

, 1998
Elizaveta Fasler‐Kan, Andreas Pansky, Michèle Wiederkehr, Manuel Battegay, Markus H. Heim   +4 more
openalex   +1 more source