Results 281 to 290 of about 527,002 (316)

Pidotimod plus recombinant human interferon α-2b suppository boosts HPV clearance in high-risk patients following loop electrosurgical excision procedure. [PDF]

Am J Transl Res
Li X, Qiu Y.
europepmc   +1 more source

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

Advanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu, Zhongzheng Sun, Yingchao Liu, Jiang Liu, Linpei Guo, Guojing Pei, Ying Jiang, Baowang Miao, Zhen Li, Ping Zhang, Dongqi Tang, Wen Zhang, Chengwei Wang   +12 more
wiley   +1 more source

Interferon Regulatory Factors as a Potential Therapeutic Target for Neuroinflammation: A Focus on Alzheimer's Disease. [PDF]

Int J Mol Sci
Fan X, Diao W, Wang H, Yin X, Qian W.
europepmc   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

Advanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee, Loi Nguyen Dang, Jinsol Choi, Haesoo Kim, Lyndon Bastatas, Soyeun Park   +5 more
wiley   +1 more source

Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop. [PDF]

Nat Commun
Willemsen L, Lee J, Shinde P, Soldevila F, Aoki M, Orfield S, Kojima M, da Silva Antunes R, Sette A, Peters B.   +9 more
europepmc   +1 more source

Transcriptome analysis to decipher the molecular underpinnings of response to treatment in systemic lupus erythematosus. [PDF]

RMD Open
Garantziotis P, Moysidou GS, Kapsala N, Flouda S, Nikolopoulos D, Chavatza K, Sentis G, Filia A, Malissovas N, Pieta A, Banos A, Katechis S, Fanouriakis A, Bertsias G, Boumpas DT.   +14 more
europepmc   +1 more source

RNF149 modulates the type I IFN innate antiviral immune responses through degrading IRF3. [PDF]

PLoS Pathog
Wu M, Cai J, Qiao G, Li X, Zhou J, Xu F, Ye Y, Wang Y, Xu X, Li J, Tian X, Shao Y, Dong C, Chen Z, Hao C, Yang Y, Zhang J.   +16 more
europepmc   +1 more source

Analysis of preoperative serum cytokine levels in patients with oral squamous cell carcinoma. [PDF]

Sci Rep
Bao Z, Yi B.
europepmc   +1 more source

Association of interferon regulator factor 1 upregulation with pulmonary arterial hypertension. [PDF]

J Thorac Dis
Ye Y, Zhou M, Yin D, Wang Y, Lin J, Sun J, Wang X, Guo Q.   +7 more
europepmc   +1 more source

Chronic lysosome damage boosts interferon responses to Palbociclib through a mitochondrial signalling axis

Bozic M, Lim TE, Kemp AJ, Winnington-Ingram K, Murphy L, Dhir A, Wheeler A, Jimenez-Moreno N, Wilkinson S.   +8 more
europepmc   +1 more source