Results 101 to 110 of about 236,667 (309)
Advanced Science, EarlyView.This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo +9 more
wiley +1 more source
[Use of recombinant alpha 2-interferon in athletes].
Voprosy virusologii, 1989 It has first been established that interferon preparations, especially reaferon, exert a protective antiviral effect in nonepidemic situations under conditions of physical and emotional stress leading to activation of opportunistic flora. Alongside with antiviral effect, reaferon showed a significant immunomodulating effect on the host reflected in ...
F I, Ershov +2 more
openaire +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
IN SILICO CHARACTERIZATION OF HUMAN INTERFERON ALPHA/BETA RECEPTOR 2 (ISOFORM A, B AND C) PROTEIN
Pakistan Armed Forces Medical Journal, 2021 Objective: To predict the tertiary structure of human interferon alpha/beta receptor 2 protein. Study Design: Structure prediction by using bio informatics tools. Place and Duration of Study: Department of Biochemistry, Swat Medical College (STMC),
Ambreen Javed +3 more
doaj
Advanced Science, EarlyView.This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou +12 more
wiley +1 more source
Th1 and Th2 cytokines are elevated in HCV-infected SVR(-) patients treated with interferon-alpha
, 2010 [[abstract]]Interferon-alpha-based treatment is a standard therapy to cure hepatitis C virus-infected patients. However, the reasons for the failure of interferon-alpha treatment in some patients have not been fully elucidated.
Wan, L (Wan, Lei); Kung, YJ (Kung, Yung-Jen); Lin, YJ (Lin, Ying-Ju); Liao, CC (Liao, Chiu-Chu); Sheu, JJC (Sheu, Jim J. C.); Tsai, YS (Tsai, Yuhsin); Lai, HC (Lai, Hsueh-Chou); Peng, CY (Peng, Cheng-Yuan); Tsai, FJ (Tsai, Fuu-Jen)
core
Eradicating chronic Hepatitis C Viraemia : lessons learnt during the last decade [PDF]
, 2005 Over the last decade a better understanding of the mechanism for immune disposal of hepatocytes infected with the Hepatitis C virus enabled the design of antiviral regimens with increasing efficacy.
Pullicino, Edgar
core
UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
Advanced Science, EarlyView.ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
, 2010 Type I interferons (IFNα and β) are induced directly in response to viral infection, resulting in an antiviral state for the cell. In vitro studies have shown that IFNα is a potent inhibitor of viral replication; however, its role in HIV-1 infection is ...
McKnight, A +5 more
core +1 more source
THE RESULT OF 12 BLADDER CARSINOMA TREATED WITH INTERFERON ALPHA 2-b
Urology Research and Practice, 2019 -
Aves Editorial Aves Editorial
doaj +2 more sources