Results 181 to 190 of about 25,282,834 (298)

Sex-dependent interferon signaling contributes to female-biased vulnerability in Alzheimer's disease. [PDF]

J Neuroinflammation
López-López V, Iniesta G, Galán-Ganga M, Expósito-Coca A, Durán-Laforet V, Bhojwani-Cabrera AM, Navarrón CM, Guillot-Fernández M, Venero JL, Sánchez-Mut JV, Barco A, Giralt A, López-Atalaya JP.   +12 more
europepmc   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Viral entry defines the hepatitis E virus species barrier in murine hepatocytes. [PDF]

Emerg Microbes Infect
Frericks N, Pinto Veiga O, Sirkinti L, Nguyen HD, Sliwinski T, Guo H, Brüggemann Y, Burkard T, Ulrich RG, Brown RJP, Tuoc T, Nguyen HP, Wang W, Todt D, Kinast V, Steinmann E.   +15 more
europepmc   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Associations between preoperative biomarkers and patient-reported outcomes after single-level lumbar discectomy: a systematic review. [PDF]

J Spine Surg
Sampath SG, Willoughby CJ, Iyer JM, Botkiss ML, Pawul C, Howell HJ, Upadhyayula PS, Khan FA, Le VP, Chahine NO, Chou D, Chan AK.   +11 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Interferon Alfa in the treatment of B-cell chronic lymphocytic leukemia [PDF]

, 1994
Knauf, W. U., Maubach, P. A., Adolf, D., Mitrou, P. S., Emmerich, B., Ziegle-Heitbrock, H. W. L., Thiel, E., Langenmayer, Irmgard, Bergmann, L., Dietzfelbinger, H., Nerl, C.   +10 more
core   +1 more source

Comparative Efficacy of Bulevirtide, Interferons, and Nucleos(t)ide Analogs for Chronic Hepatitis Delta: A Systematic Review and Network Meta-Analysis. [PDF]

Int J Hepatol
Karkra R, Mohsen M, Pagán-Busigó JE, Shamsian E, Bebawy M, Rella S, Tafesh Z, Gaglio P.   +7 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Interferon-induced interstitial lung disease: a rare adverse effect induced by pegylated interferon-alpha in a patient with chronic hepatitis B-case report. [PDF]

BMC Pulm Med
Yu H, Zhang S, Zhou Y, Wen Q, Wang Y, Yang X.   +5 more
europepmc   +1 more source