Results 121 to 130 of about 80,233 (311)
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
The Use of Species Specific Interferons in Veterinary Medicine [PDF]
, 2016 Interferons are cytokines, a type of signaling proteins involved in immune response that are released by affected cells in situations such as the invasion of viruses, bacteria, or parasites. Currently, human recombinant interferons are used in veterinary
Peetoom, Jaci +3 more
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Arthritis Care &Research, EarlyView.Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato +27 more
wiley +1 more source
Type 1 interferons in early rheumatoid arthritis [PDF]
, 2017 PhD ThesisRheumatoid arthritis (RA) is a heterogeneous autoimmune disease predominantly causing synovial inflammation. Early and established RA exhibit both overlapping and distinct pathological processes.
Cooles, Faye Anisa Hogarth
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From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis
Arthritis Care &Research, Accepted Article.Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss +9 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
Syntenic localization of bovine genes for class I alpha interferons, beta interferons, fibronectin, and growth hormone [PDF]
, 1986 Typescript (photocopy).The bovine genes for class I alpha interferons, beta interferons, fibronectin, and growth hormone have been localized to syntenic groups.
Adkison, Linda Russell
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Frontiers in MedicineBackgroundMany studies have shown that cytokines play an important role in the pathogenesis of asthma, but their biological effects on asthma remain unclear.
Yansen Zheng +4 more
doaj +1 more source
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
IFNs in host defence and parasite immune evasion during Toxoplasma gondii infections
Frontiers in ImmunologyInterferons (IFNs) are a family of cytokines with diverse functions in host resistance to pathogens and in immune regulation. Type II IFN, i.e. IFN-γ, is widely recognized as a major mediator of resistance to intracellular pathogens, including the ...
Carsten G. K. Lüder
doaj +1 more source