Results 101 to 110 of about 87,441 (309)

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

Threonine Phosphorylation and the Yin and Yang of STAT1: Phosphorylation-Dependent Spectrum of STAT1 Functionality in Inflammatory Contexts

Cells
Threonine phosphorylation promotes inflammatory functions of STAT1 while restricting its interferon (IFN) signaling in innate immune responses. However, it remains unclear whether the restriction of STAT1-mediated IFN signaling conferred by threonine ...
Maha M. Elbrashy, Hozaifa Metwally, Shuhei Sakakibara, Tadamitsu Kishimoto   +3 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

The Effect of Interferon, Interferon Inducers or Interferon Induced Virus Resistance on Subsequent Interferon Production

Journal of General Virology, 1972
Summary The pre-treatment of mouse L cells with interferon or polyinosinic-polycytidylic acid potentiated the interferon response of these cells to subsequent stimulation with suboptimal doses of polyinosinic-polycytidylic acid. This potentiation was manifested as an earlier production of interferon, a faster attainment of maximum interferon production,
S A, Margolis, H, Oie, H B, Levy
openaire   +2 more sources

Chicken interferons, their receptors and interferon-stimulated genes

, 2013
Chicken interferons, their receptors and interferon-stimulated ...
K Goossens (13553692), J Lowenthal (13300758), Alister Ward (13059717), A Bean (13291275)   +3 more
core  

Azathioprine versus beta interferons for relapsing-remitting multiple sclerosis: A multicentre randomized non-inferiority trial [PDF]

, 2014
For almost three decades in many countries azathioprine has been used to treat relapsing-remitting multiple sclerosis. However its efficacy was usually considered marginal and following approval of beta interferons for this indication it was no longer ...
Tedeschi, Gioacchino, Filippini, G., Graziella Filippini, Tramacere, Irene, Clara Milanese (662309), BENEDETTI, MARIADONATA, Salvatore Amoroso (174295), Milanese, Clara, Clara Milanese, Battaglia, Mario Alberto, Gioacchino Tedeschi, Battaglia, Mario A., Amoroso, Salvatore, Loredana La Mantia (662306), Anna Repice (662307), Massacesi, Luca, Mario A Battaglia, Luca Massacesi (662301), Battaglia, M. A., Repice, Anna, Solari, Alessandra, Irene Tramacere (662302), La Mantia, Loredana, Anna Repice, Alessandra Solari, Salvatore Amoroso, Amoroso, S., Filippini, Graziella, Maria Donata Benedetti, Graziella Filippini (662305), Repice, A., Milanese, C., Alessandra Solari (397759), Tedeschi, G., Gioacchino Tedeschi (662308), Loredana La Mantia, Benedetti, Maria Donata, La Mantia, L., Tramacere, I., Maria Donata Benedetti (662304), Solari, A., Luca Massacesi, Mario A. Battaglia (662303), Massacesi, L., Repice, Anna Maria Rita, Irene Tramacere, Massacesi Luca, Benedetti Maria Donata, Tedeschi Gioacchino, Milanese Clara, Amoroso Salvatore, La Mantia Loredana, Solari Alessandra, Battaglia Mario A., Tramacere Irene, Filippini Graziella, Repice Anna   +56 more
core   +2 more sources

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

The Use of Species Specific Interferons in Veterinary Medicine

, 2016
Interferons are cytokines, a type of signaling proteins involved in immune response that are released by affected cells in situations such as the invasion of viruses, bacteria, or parasites. Currently, human recombinant interferons are used in veterinary
Peetoom, Jaci, Kimble, Shane, Trubitsyn, Denis, Patapovich, Maksim   +3 more
core   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages

mBio, 2018
Phagocytic cells are the first line of innate defense against intracellular pathogens, and yet Toxoplasma gondii is renowned for its ability to survive in macrophages, although this paradigm is based on virulent type I parasites.
Sumit K. Matta, Kelley Patten, Quiling Wang, Bae-Hoon Kim, John D. MacMicking, L. David Sibley   +5 more
doaj   +1 more source