Results 191 to 200 of about 223,138 (357)

Attenuation of Influenza a Virus into Live Vaccines Through C‐End Degrons

Advanced Science, EarlyView.
Naturally occurring C‐end degrons are exploited to design proteolysis‐targeting live attenuated influenza vaccines. C‐end degron tagging of viral M1 protein promotes proteasome‐dependent degradation, resulting in robust attenuation in host cells while permitting scalable production in engineered cells.
Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen‐xia Tian, Longlong Si   +14 more
wiley   +1 more source

Type I interferons in inflammatory bowel diseases: balancing barrier integrity, repair and inflammation in the intestinal epithelium. [PDF]

Front Med (Lausanne)
King MR, Kemp RA, Gadeock S.
europepmc   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

"Cytokine-Mediated tumor sensitization: mechanistic frameworks and therapeutic opportunities in cancer Immunotherapy". [PDF]

Clin Exp Med
Aghaei M, Bahreiny SS, Mahdizade AH, Abbasi A, Magharati A, Yousefi-Avarvand A.   +5 more
europepmc   +1 more source

DDX58(RIG-I)-related disease is associated with tissue-specific interferon pathway activation

, 2021
Lev Prasov, Brenda L. Bohnsack, Antonette Souto El Husny, Lam C. Tsoi, Bin Guan, J. Michelle Kahlenberg, Edmundo Frota de Almeida, Haitao Wang, Edward W. Cowen, Adriana A. de Jesus, Priyam Jani, Allison C. Billi, Sayoko E. Moroi, Rachael Wasikowski, Izabela Almeida, Luciana Negrão Frota de Almeida, Fernando Kok, Sarah J. Garnai, Shahzad I. Mian, Marcus Y. Chen, Blake M. Warner, Carlos R. Ferreira, Raphaela Goldbach‐Mansky, Sun Hur, Brian P. Brooks, Julia E. Richards, Robert B. Hufnagel, Jóhann E. Guðjónsson   +27 more
openalex   +2 more sources

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Alpha-interferon induced acute renal allograft rejection [PDF]

, 1995
Holley, JL, Johnson, JP, Jordan, M, Magnone, M, McCauley, J, Scantlebury, V, Shapiro, R, Starzl, T, Vivas, C   +8 more
core  

Investigation of Porcine Interferons as a metaphylactic intervention strategy against Classical Swine Fever Virus (CSFV) [PDF]

, 2015
Crooke, H, Crudgington, B, Everett, H, Skinner, M   +3 more
core   +1 more source

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

Protective and pathogenic: The Janus-faced role of cGAS-STING in the brain. [PDF]

J Cereb Blood Flow Metab
Corona C, Kanzlemar C, Hussaini A, Ratan RR.   +3 more
europepmc   +1 more source