Results 281 to 290 of about 223,138 (357)

Attenuated Bacteria‐Based Tumor Therapy: Clinical Application Risks, Marketing Approval Restrictions, and Coping Strategies

Advanced Science, EarlyView.
This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu, Junhong Yao, Jiaxin Deng, Minjie Zhou, Kaiyue Shen, Shishuo Sun, Xiaoge Gao, Qing Zhang, Haiheng Xu   +8 more
wiley   +1 more source

Interferons Inhibit Ebola Virus Infection of Human Keratinocytes. [PDF]

Viruses
Elliff J, Van Ert H, Sevcik K, Djurkovic MA, Rudd D, Gourronc F, Klingelhutz A, Shtanko O, Maury W.   +8 more
europepmc   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Exosomes derived from avian influenza virus-infected chickens modulate host immune responses. [PDF]

Poult Sci
Kim C, Phan TH, Truong AD, Hong YH.
europepmc   +1 more source

Synergistic Mn‐MOF Activation of Pistol Ribozymes for Cancer Immunotherapy

Advanced Science, EarlyView.
A Mn2+‐based metal–organic framework delivers a catalytic Pistol ribozyme for targeted PD‐L1 mRNA cleavage in tumor cells, with the released Mn2+ not only inducing immune activation in immune cells but also increasing the Pistol ribozyme catalytic activity.
Ming Zhao, Shan Qiao, Jie Bai, Jingjing Zhang, Zhiqin Xi, Zhenzhen Li, Xuelin Zhan, Ying Zhang, Xiaotong Yu, Yao Chen, Yijin Liu   +10 more
wiley   +1 more source

Updates on the Role of Innate Immunity's Pattern Recognition Receptors in Vitiligo Pathogenesis and Therapeutic Potential. [PDF]

Clin Cosmet Investig Dermatol
Feng J, Lu L, He H, Peng Y, Zhang S, Yang L, Liu Y, Wang T.   +7 more
europepmc   +1 more source

Contrasting immune responses in COVID-19: insights from healthcare workers and infected patients on plasmablast, pDC, and NK cell dynamics. [PDF]

Front Immunol
Martín-Pedraza L, Rodríguez-Martín E, De La Torre-Tarazona E, Moreno E, Pariente-Rodríguez R, Walo-Delgado PE, García-Pérez J, Díaz J, Luna L, Rodríguez-Dominguez M, Galán JC, Geraldine Rita C, Del Amo-de Palacios A, Navarro-Soler R, Fons M, Alcamí J, Moreno S, Villar LM, Serrano-Villar S.   +18 more
europepmc   +1 more source

Expression Patterns of Interferons and Proinflammatory Cytokines in the Upper Respiratory Tract of Patients Infected by Different Viral Pathogens: Correlation with Age and Viral Load. [PDF]

Biomolecules
Ferrarese R, Novazzi F, Arcari G, Genoni A, Drago Ferrante F, Clementi N, Messali S, Pitrolo AMG, Caccuri F, Piralla A, Caruso A, Baldanti F, Mancini N.   +12 more
europepmc   +1 more source

Interferons in Autoimmunity: From Loss of Tolerance to Chronic Inflammation. [PDF]

Biomedicines
Mihaescu G, Gradisteanu Pircalabioru G, Roznovan CN, Ditu LM, Comanici MM, Savu O.   +5 more
europepmc   +1 more source

TLR agonists as adjuvants for viral vaccines: mechanisms, applications, and future directions. [PDF]

Front Microbiol
Shao F, Zhu X, Yi M, Gao H, Wu J, Fang R, Xie Y, Han J, Lu H.   +8 more
europepmc   +1 more source