Results 41 to 50 of about 104,171 (260)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Brain-based learning in design and visual arts education: a bibliometric assessment of Scopus indexed literature [version 3; peer review: 2 approved, 1 not approved]

F1000Research, 2023
Background: This study aims to critically review, quantify, and assess research outcomes on brain-based learning with an evidence-based study on Scopus indexed literature, with a focus to understand the evolution structure and growth, detect trends ...
Hala A. El-Wakeel, Khadeeja M N Ansari, Dalia Hussain Eldardiry, Reham Abdellatif, Mai I. Shukri, Deema F. Al-Saleh   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The evolution of heritage approach in contemporary architecture and interior design from the 18th century to the 20th century

Journal of Architecture, Art & Humanistic Science
with the continuous changes in human life and the conflict between heritage and between modernity, contemporaneity and advanced technologies, we must emulate the creative thought and principles of designs used by our ancestors and mix them into what ...
Prof. Dalal Yousr-Allah Mohamed Professor of Environmental Design in Interior and Furniture Design Former Head of Decoration& Interior Architecture at The Higher Institute of Applied Arts -6th Of October, Prof. Hassan Abdo Mohamed Professor of Design at Interior Design & Furniture Department -Faculty of Applied Arts Helwan University   +1 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The impact of social customs and cultural heritages on human behavior and use of different elements of internal spaces

Journal of Architecture, Art & Humanistic Science
This research seeks to understand human behavior and its interest in interfering with the social and cultural customs of society with the aim of integrating the culture of society with acquired human behavior.
Prof. Dr. Ismael Awad Interior Design & Furniture Department – Faculty Of Applied Arts – Helwan University, Prof. Dr. Ahmed Mohamed Safi El-Din Interior Design & Furniture Department – Faculty Of Applied Arts – Banyswaif University   +1 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Furniture Designer Harmonizes Between Stereotype and Creativity to Solve Design Problems

Journal of Architecture, Art & Humanistic Science
Stereotypical thinking is not defective, and it is a state of important and essential thinking that we need in many aspects of the design process.
Prof/ Ashraf Hussein Ibrahim, Professor of Interior Design and Furniture, Faculty of Applied Arts   +1 more
doaj   +1 more source

The Effect Of The Education Systems Applied In Pre-School Educational Institutions On The Place Formation And Essays On The Place Design Provided By Reggio Emilia Education System

Megaron, 2016
In a country, the earnings of the young population during education, shape the cornerstone of the country's future. When the program contents of the education policies, which are important for the determination of countries' future visions, are examined,
Didem Erten Bilgic, Amrela Sany Surur
doaj   +1 more source