Results 201 to 210 of about 95,584 (290)

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, Volume 292, Issue 11, Page 2865-2881, June 2025.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

Non-Rhizobial Endophytes (NREs) of the Nodule Microbiome Have Synergistic Roles in Beneficial Tripartite Plant-Microbe Interactions. [PDF]

Microorganisms
Hassen AI, Muema EK, Diale MO, Mpai T, Bopape FL.   +4 more
europepmc   +1 more source

Neural Metabolic Networks: Key Elements of Healthy Brain Function

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School (2022). Here, we describe how the specific bioenergetic profiles and metabolic exchanges between brain cells enable and gate synaptic function and behavior. Then, based on this analysis, we discuss the potential role
Nimrod Madrer, Nirma D. Perera, Nonthué A. Uccelli, Alice Abbondanza, Jens V. Andersen, Emma Veronica Carsana, Matthew D. Demmings, Regina F. Fernandez, Matheus Garcia de Fragas, Ismail Gbadamosi, Divita Kulshrestha, Ricardo A. S. Lima‐Filho, Oana C. Marian, Kia H. Markussen, Andrew J. McGovern, Elliott S. Neal, Sukanya Sarkar, Eva Šimončičová, Jazmín Soto‐Verdugo, Sozerko Yandiev, Ignacio Fernández‐Moncada   +20 more
wiley   +1 more source

Assessing the Quality of Democracy: A Practical Guide [PDF]

, 2008
Beetham, D, Carvalho, E, Landman, T, Weir, S   +3 more
core  

The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Ndr2 participates in the T788/789 phosphorylation of the integrin β1 integrin subunit. Ndr2 deficiency reduces synaptic density, diminishes CA1 LTP, and impairs spatial memory. Activation of integrins restores the plasticity impairment of Ndr2 deficient mice. Ndr2 is involved in integrin‐dependent synapse formation and plasticity in the hippocampus CA1.
Del Angel, Atsuhiro Tsutiya, Hussam Hayani, Deniz Madencioglu, Emre Kul, Gürsel Caliskan, Yunus Emre Demiray, Alexander Dityatev, Oliver Stork   +8 more
wiley   +1 more source

Nanopores with an Engineered Selective Entropic Gate Detect Proteins at Nanomolar Concentration in Complex Biological Sample. [PDF]

J Am Chem Soc
Straathof S, Di Muccio G, Maglia G.
europepmc   +1 more source

Elucidating the enzyme network driving Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum

Plant Biotechnology Journal, Volume 23, Issue 6, Page 1988-2005, June 2025.
Schematic representation of Amaryllidaceae alkaloid biosynthesis in Leucojum aestivum. Norbelladine synthase (LaNBS) and noroxomaritidine/norcraugsodine reductase (LaNRII) catalyze the condensation of tyramine and 3,4‐dihydroxybenzaldehyde to form norbelladine, which is subsequently O‐methylated by norbelladine‐4′‐O‐methyltransferase (LaN4′OMT ...
Basanta Lamichhane, Sarah‐Eve Gélinas, Natacha Merindol, Manoj Koirala, Karen Cristine Gonçalves dos Santos, Hugo Germain, Isabel Desgagné‐Penix   +6 more
wiley   +1 more source

Nuclear position and local acetyl-CoA production regulate chromatin state. [PDF]

Nature
Willnow P, Teleman AA.
europepmc   +1 more source

Spatial Proteomics by Parallel Accumulation‐Serial Fragmentation Supported MALDI MS/MS Imaging: A First Glance Into Multiplexed and Spatial Peptide Identification

Rapid Communications in Mass Spectrometry, Volume 39, Issue 9, 15 May 2025.
ABSTRACT Rationale In spatial proteomics, matrix‐assisted laser desorption/ionization (MALDI) imaging enables rapid and cost‐effective peptide measurements. Yet, in situ peptide identification remains challenging. Therefore, this study aims to integrate the trapped ion mobility spectrometry (TIMS)–based parallel accumulation‐serial fragmentation (PASEF)
Mujia Jenny Li, Larissa Chiara Meyer, Nadine Meier, Jannik Witte, Maximilian Maldacker, Adrianna Seredynska, Julia Schueler, Oliver Schilling, Melanie Christine Föll   +8 more
wiley   +1 more source

Early-life contact with non-maternal adult cows and a pasture-based rearing environment influence behavioural responses of dairy heifers to novelty. [PDF]

Anim Welf
Field L, Hemsworth L, Jongman E, McGill D, Verdon M.   +4 more
europepmc   +1 more source