Results 211 to 220 of about 42,894 (279)

Metabolic Profiling Reveals a Glycolytic Shift and an IRG1/Itaconate/NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
Microglia, the brain's immune cells, change their metabolism depending on whether they are fighting infection or promoting healing. This study shows that during inflammation, microglia increase a molecule called itaconate, which helps reduce harmful stress in the brain while still allowing an immune response.
Pinelopi Engskog‐Vlachos, Mikael K. R. Engskog, Martin Skandik, Kathleen Grabert, Noah Moruzzi, Marie‐Kim St‐Pierre, Ahmed M. Osman, Theodora Sylaidi, Klas Blomgren, Per‐Olof Berggren, Bertrand Joseph   +10 more
wiley   +1 more source

The role of the North American continent in strengthening the Asian summer monsoon. [PDF]

Sci Adv
Chen L, Valdes PJ, Farnsworth A.
europepmc   +1 more source

Dynamic changes in Ccn3 expression across the limbic forebrain through the mouse estrous cycle and during lactation

Journal of Neuroendocrinology, Volume 37, Issue 9, September 2025.
Abstract Cellular communication network factor 3 (CCN3), also known as nephroblastoma overexpressed (NOV), is an adipocytokine that has recently been suggested to be secreted selectively by hypothalamic arcuate nucleus kisspeptin (ARNKISS) neurons to protect bone density during lactation. Using RNAscope hybridization, we have examined the expression of
Shel‐Hwa Yeo, Zulfiye Gul, Ziyue Zhou, Leila Muresan, Ellen G. Wall, Allan E. Herbison   +5 more
wiley   +1 more source

Early-life contact with non-maternal adult cows and a pasture-based rearing environment influence behavioural responses of dairy heifers to novelty. [PDF]

Anim Welf
Field L, Hemsworth L, Jongman E, McGill D, Verdon M.   +4 more
europepmc   +1 more source

TROP2 Expression in Salivary Gland Adenoid Cystic Carcinoma (ACC) According to Histologic Subtype: Therapeutic Implications

Journal of Oral Pathology &Medicine, Volume 54, Issue 8, Page 658-666, September 2025.
ABSTRACT Background Adenoid cystic carcinoma (ACC) is a common salivary gland carcinoma with high recurrence and distant metastasis rates. Currently, there is no standard systemic treatment available. TROP2 is a transmembrane glycoprotein involved in the oncogenesis of several tumors that can be therapeutically targeted by a TROP2‐antibody–drug ...
Juliana Mota Siqueira, Yoshitsugu Mitani, Mario L. Marques‐Piubelli, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mutsumi Mitani, Giovanna Lopes Carvalho, Fabio Daumas Nunes, Leandro Luongo Matos, Shiaw‐Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El‐Naggar, Renata Ferrarotto   +15 more
wiley   +1 more source

Nuclear position and local acetyl-CoA production regulate chromatin state. [PDF]

Nature
Willnow P, Teleman AA.
europepmc   +1 more source

DASH: a versatile and high‐capacity gene stacking system for plant synthetic biology

Plant Biotechnology Journal, Volume 23, Issue 9, Page 3697-3712, September 2025.
Summary DNA assembly systems based on the Golden Gate method are popular in synthetic biology but have several limitations: small insert size, incompatibility with other cloning platforms, DNA domestication requirement, generation of fusion scars, and lack of post‐assembly modification.
Chengsong Zhao, Anna N. Stepanova, Jose M. Alonso   +2 more
wiley   +1 more source

Nanopores with an Engineered Selective Entropic Gate Detect Proteins at Nanomolar Concentration in Complex Biological Sample. [PDF]

J Am Chem Soc
Straathof S, Di Muccio G, Maglia G.
europepmc   +1 more source

TCP19 regulates nitrogen‐dependent sheath blight susceptibility by modulating nitrogen uptake and signalling in rice

Plant Biotechnology Journal, Volume 23, Issue 9, Page 4140-4157, September 2025.
Summary The excessive application of nitrogen fertilization improves rice yield, but increases disease severity. However, the underlying molecular mechanisms remain unclear. Here, we conducted a comparative analysis of nitrogen‐ and R. solani‐regulated transcriptomes and identified TEOSINTE BRANCHED, CYC, PCF 19 (TCP19), that was a key regulator of ...
Tiange Zhou, Huan Chen, Xu Jiang, Hongyao Zhu, Qiujun Lin, Ki‐Hong Jung, Xiaofeng Zhu, Yuan Hu Xuan   +7 more
wiley   +1 more source

Type II diabetes and cognitive function among older adults in India and China-results from Harmonized Cognitive Assessment Protocol studies. [PDF]

Front Public Health
Srikantha S, Manne-Goehler J, Kobayashi LC, Flood D, Koton S, Gross AL.   +5 more
europepmc   +1 more source