Results 81 to 90 of about 6,729,326 (226)
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Investigating the interplay between excitatory neurotransmission and GABAa receptor expression and trafficking in the stargazer mutant mouse [PDF]
, 2006 The stargazer mutant mouse is an animal model of human absence epilepsy and cerebellar ataxia. The stargazer mutation results in the complete ablation of expression of TARPy2， an AMPA receptor (AMPAR) auxiliary subunit.
Payne, Helen Louise
core
Advanced Science, EarlyView.This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy +7 more
wiley +2 more sources
Characterization of a gp130 Signaling Receptor Polymorphism [PDF]
, 2013 We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
core
Developmental changes in voltage-gated calcium channel α(2)δ-subunit expression in the canine dorsal root ganglion [PDF]
, 2012 The voltage-gated calcium channel subunit (128 plays a fundamental role in propagation of excitatory signals associated with release of glutamate and neuropeptides substance P (SP) and calcitonin gene-related protein (CGRP).
K. Matiasek +18 more
core +1 more source
Intelligent Programmable Membrane Nanosponge for Early Virus Blocking
Advanced Science, EarlyView.A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen +17 more
wiley +1 more source
Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis
Advanced Science, EarlyView.Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang +9 more
wiley +1 more source
Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors [PDF]
, 2002 GABA(A) receptors are the principal sites of fast synaptic inhibition in the brain. These receptors are hetero-pentamers that can be assembled from a number of subunit classes: alpha(1-6), beta(1-3), gamma(1-3), delta(1), epsilon, theta, and pi, but the ...
Trevor G Smart +7 more
core
Advanced Science, EarlyView.Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang +14 more
wiley +1 more source