Results 161 to 170 of about 441,802 (306)

Association of Long Non-Coding RNA Malat1 with Serum Levels of Interleukin-1 Beta and Vitamin D in Patients with Ischemic Stroke. [PDF]

open access: yesGalen Med J, 2023
Bayat M   +8 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

open access: yesAdvanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu   +4 more
wiley   +1 more source

Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing

open access: yesAdvanced Science, EarlyView.
This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang   +10 more
wiley   +1 more source

Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids

open access: yesDrug Design, Development and Therapy, 2015
Ru Wang, Junjie Chen, Zhenyu Zhang, Ying CenDepartment of Burn and Plastic Surgery, West China Hospital of Sichuan University, Chengdu, People’s Republic of ChinaBackground: Histologically, keloids contain excess fibroblasts and an overabundance of
Wang R, Chen J, Zhang Z, Cen Y
doaj  

Association of Common Polymorphisms in the Interleukin-1 Beta Gene with Hepatocellular Carcinoma in Caucasian Patients with Chronic Hepatitis B. [PDF]

open access: yesPathogens, 2022
Fischer J   +12 more
europepmc   +1 more source

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

open access: yesAdvanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao   +28 more
wiley   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

open access: yesAdvanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou   +22 more
wiley   +1 more source

Anakinra and related drugs targeting interleukin-1 in the treatment of cryopyrin- associated periodic syndromes

open access: yesOpen Access Rheumatology: Research and Reviews, 2014
Inessa Bachove,1 Christopher Chang2 1Cooper University Hospital, Children's Regional Hospital, Camden, NJ, USA; 2Division of Allergy and Immunology, Thomas Jefferson University, Wilmington, DE, USA Abstract: Anakinra is an interleukin (IL) receptor ...
Bachove I, Chang C
doaj  

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