Interleukin-1 beta - Open Access .click

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Differential biological activities of human interleukin-1 alpha and interleukin-1 beta.

European cytokine network, 1991
We examined the biological effects induced by both human recombinant interleukin-1 alpha (IL-1 alpha) and beta (IL-1 beta) in five different cell types of human, rat and mouse origin. IL-1 alpha and beta preparations were standardized in terms of biological activity in the EL-4/CTLL bioassay and, in parallel, employed to stimulate PGE2 secretion in ...
H H, Radeke +4 more
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The proteolytic activation of interleukin-1 beta.

Agents and actions. Supplements, 1992
Interleukin-1 beta (IL-1 beta) is released from an inactive precursor by a proteolytic cleavage. A monocytic protease has been identified that appears to be involved in the physiological activation of this cytokine. Two situations have been found in which precursor IL-1 beta exists without the monocytic processing enzyme, and in these cases other ...
R, Black +6 more
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Interleukin-1 beta and interleukin-1 alpha stimulate the N-acetyl-beta-glucosaminidase activity of human synovial cells.

Rheumatology international, 1988
The properties of synovial cells are altered in vitro by monocyte-macrophage polypeptides (monokines), and these changes could explain some of the properties of the inflamed synovium in rheumatoid disease. Purified monokines have become available only recently for testing on the target synovial cells. We report here that purified human interleukin (IL)-
B J, Clarris +4 more
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Pro-interleukin-1 beta and mature interleukin-1 beta in human trophoblast