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Interleukin-1 Receptor Antagonist Gene (IL1RN) Variants Modulate the Cytokine Release Syndrome and Mortality of COVID-19. [PDF]
Attur M +9 more
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Case report: Novel compound heterozygous IL1RN mutations as the likely cause of a lethal form of deficiency of interleukin-1 receptor antagonist. [PDF]
Urbaneja E +11 more
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Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells [PDF]
Abou-Ezzi, Grazia +17 more
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Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Nature, 1990Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations ...
C H, Hannum +9 more
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INTERLEUKIN-1 RECEPTOR ANTAGONIST
Rheumatic Disease Clinics of North America, 1998There are three members of the IL-1 gene family: IL-1 alpha, IL-1 beta, and IL-1ra, IL-1 alpha, and IL-1 beta are both antagonist molecules with many proinflammatory effects. IL-1ra is an antagonist molecule that can inhibit the effect of IL-1 alpha and IL-1 beta by specifically blocking the IL-1 receptor on target effector cells.
B, Bresnihan, G, Cunnane
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